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【medical-news】孕妇长期紧张增加后代脑瘫风险
Mild stress in the womb may worsen risk of cerebral palsy
WASHINGTON, DC July 11, 2007 -- Chronic mild stress in pregnant mothers may increase the risk that their offspring will develop cerebral palsy—a group of neurological disorders marked by physical disability—according to new research in mice. The results may be the first to demonstrate such effects of stress on animals in the womb.
The new study, led by Pierre Gressens, MD, PhD, of Inserm in France, used a mouse model to test whether exposure to minimal but repeated stress throughout gestation would make the offspring more vulnerable to brain lesions similar to those observed in children with cerebral palsy. The findings are published in the July 11 issue of The Journal of Neuroscience. Inserm, l'Institut national de la santé et de la recherche médicale, is the French public biomedical research agency.
“These findings are consistent with growing evidence that constant stress, even minimal, can have a major impact on the quality of life,” says Victoria Luine, PhD, distinguished professor of psychology at New York’s Hunter College, who did not participate in the research.
In the study, the scientists adjusted the normal cycle of light and dark that the pregnant mice were accustomed to for half of the mice, subjecting them to a mild level of stress. Then the researchers exposed the brains of the developing fetuses to injury. When the brains of the young mice were examined on birth, Gressens and his team found that the offspring born from stressed mothers showed brain lesions about twice as big as those in offspring of unstressed mothers.
“Determining the impact of gestational stress on the incidence of cerebral palsy would be of paramount interest,” says Gressens. “Limiting stress during human pregnancy might prove to be a cost-efficient way to reduce the human, emotional, social and economic burden of cerebral palsy.”
http://www.eurekalert.org/pub_releases/2007-07/sfn-msi070907.php Public release date: 10-Jul-2007
孕期的轻度紧张增加脑瘫的危险性
Mild stress in the womb may worsen risk of cerebral palsy
华盛顿区，2007年7月11日－－根据小鼠中的新研究，怀孕母亲的慢性紧张可能增加她们后代发生脑瘫－－一组以体力受损为标志的神经疾病－－的危险。这些结果可能是首次证明子宫中动物的压力的这种效果。
WASHINGTON, DC July 11, 2007 -- Chronic mild stress in pregnant mothers may increase the risk that their offspring will develop cerebral palsy—a group of neurological disorders marked by physical disability—according to new research in mice. The results may be the first to demonstrate such effects of stress on animals in the womb.
法国的Inserm的Pierre Gressens双博士领导的这个新研究，使用了一种老鼠模型来检测是否在孕期暴露于最小量但是反复的压力可使后代更容易发生与在儿童脑瘫中观察到的类似的病灶。这个发现在7月11日的《神经科学》杂志发表。Inserm, l'Institut national de la santé et de la recherche médicale是法国的公共生物医学研究机构。
The new study, led by Pierre Gressens, MD, PhD, of Inserm in France, used a mouse model to test whether exposure to minimal but repeated stress throughout gestation would make the offspring more vulnerable to brain lesions similar to those observed in children with cerebral palsy. The findings are published in the July 11 issue of The Journal of Neuroscience. Inserm, l'Institut national de la santé et de la recherche médicale, is the French public biomedical research agency.
“这些发现与表明持续的压力，即使微小，对生活治疗有大的影响的增加的证据一致”，Victoria Luine博士，纽约Hunter学院的出色的心理学教授说。他没有参加这个研究。
“These findings are consistent with growing evidence that constant stress, even minimal, can have a major impact on the quality of life,” says Victoria Luine, PhD, distinguished professor of psychology at New York’s Hunter College, who did not participate in the research.
在这个研究中，科学家对一半的老鼠调整孕鼠熟悉的正常的光线和黑暗周期，使他们感受轻微水平的压力。然后研究者把发育中的胎鼠的脑暴露于损伤。当出生时幼鼠的脑进行检查，Gressens和他的小组发现压力母亲生出的后代显示的脑部病灶是未受压力母亲的后代的病灶的2倍。
In the study, the scientists adjusted the normal cycle of light and dark that the pregnant mice were accustomed to for half of the mice, subjecting them to a mild level of stress. Then the researchers exposed the brains of the developing fetuses to injury. When the brains of the young mice were examined on birth, Gressens and his team found that the offspring born from stressed mothers showed brain lesions about twice as big as those in offspring of unstressed mothers.
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作者:admin@医学,生命科学 2011-02-19 17:12
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