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【medical-news】从基因方面解释为什么有的人易患
High blood levels of triglycerides, a major form of dietary fat, have been linked to human heart disease. To identify genes that contribute to interindividual differences in the body's handling of dietary triglycerides, Pollin et al. (p. 1702) performed a genome-wide association study of volunteers from the Lancaster Amish population whose blood triglyceride levels had been measured before and after consumption of a milkshake. Individuals with the lowest levels of blood triglycerides were found to be heterozygous carriers of a null mutation in the gene encoding an inhibitor of triglyceride hydrolysis, called apolipoprotein C-III (apoC-III). These individuals, who produce half the normal amount of apoC-III, also had a favorable cholesterol profile and coronary calcification score, suggesting that they are less likely to develop cardiovascular disease.
SCIENCE, Volume 322, Issue 5908
December 12 2008
http://www.sciencemag.org/content/vol322/issue5908/twis.dtl 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Genes, Triglycerides, and Heart Health
基因、甘油三酯与心脏健康
High blood levels of triglycerides, a major form of dietary fat, have been linked to human heart disease.
血液中甘油三酯-食物脂肪的主要形式-水平与人类心脏疾病有相关性。
To identify genes that contribute to interindividual differences in the body's handling of dietary triglycerides, Pollin et al. (p. 1702) performed a genome-wide association study of volunteers from the Lancaster Amish population whose blood triglyceride levels had been measured before and after consumption of a milkshake.
为了了解基因对机体处理饮食中甘油三酯的人与人之间差别的影响，Pollin等人(p. 1702)通过检测来自Lancaster地区的门诺教人群的志愿者食用乃昔前后血液中甘油三酯水平来进行基因相关性的研究。
Individuals with the lowest levels of blood triglycerides were found to be heterozygous carriers of a null mutation in the gene encoding an inhibitor of triglyceride hydrolysis, called apolipoprotein C-III (apoC-III). These individuals, who produce half the normal amount of apoC-III, also had a favorable cholesterol profile and coronary calcification score, suggesting that they are less likely to develop cardiovascular disease.
研究者发现血液中甘油三酯水平低的人染色体为杂合子，其编码甘油三酯抑制因子-载脂蛋白C-III (apoC-III)的基因中存在无效突变。这些人的apoC-III水平只有正常人的一半，而他们的血液中的优化胆固醇结构和较低的冠脉钙化指数，提示他们更不容易罹患冠心病。
SCIENCE, Volume 322, Issue 5908
December 12 2008
科学，322卷，5908期
2008年12月12日
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基因、甘油三酯与心脏健康
血液中甘油三酯-食物脂肪的主要形式-水平与人类心脏疾病有相关性。为了了解基因对机体处理饮食中甘油三酯的人与人之间差别的影响，Pollin等人(p. 1702)通过检测来自Lancaster地区的门诺教人群的志愿者食用乃昔前后血液中甘油三酯水平来进行基因相关性的研究。研究者发现血液中甘油三酯水平低的人染色体为杂合子，其编码甘油三酯抑制因子-载脂蛋白C-III (apoC-III)的基因中存在无效突变。这些人的apoC-III水平只有正常人的一半，而他们的血液中的优化胆固醇结构和较低的冠脉钙化指数，提示他们更不容易罹患冠心病。
科学，322卷，5908期
2008年12月12日 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-19 05:20
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