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【bio-news】良性肿瘤与恶性肿瘤的差异
ScienceDaily (Jan. 5, 2011) — Cancer cells reproduce by dividing in two, but a molecule known as PML limits how many times this can happen, according to researchers led by Dr. Gerardo Ferbeyre of the University of Montreal's Department of Biochemistry. The team showed that malignant cancers have problems with this molecule, meaning that in its absence they can continue to grow and eventually spread to other organs. Importantly, the presence of PML molecules can easily be detected, and could serve to diagnose whether a tumor is malignant or not.
"We discovered that benign cancer cells produce the PML molecule and display abundant PML bodies, keeping them in a dormant, senescent state. Malignant cancer cells either don't make or fail to organize PML bodies, and thus proliferate uncontrollably," Ferbeyre explained. Senescence is the mature stage in a cell's life at which in can no longer reproduce and it is a natural defense against cancer formation. When tumor cells are benign, it means that they cannot spread or grow into other parts of the body.
The team of researchers based both on campus and at the University of Montreal Hospital Research Centre built on Dr. Ferbeyre's prior discovery that PML is able to force cells to enter senescence. However, for the past ten years, the mechanism by which this was achieved remained mostly unknown. Hospital researchers worked with patients to collect samples that enabled the team to make their discovery.
"Our findings unravel the unexpected ability of PML to organize a network of tumor suppressor proteins to repress the expression or the amount of other proteins required for cell proliferation," explained researcher Véronique Bourdeau. Such proteins are essential molecules in our body that play a key role in controlling the birth, growth and death of cells. Researcher Mathieu Vernier emphasized that "this is an important finding with implications for our understanding on how the normal organism defends itself from the threat of cancer."
The work offers exciting avenues for future research. "Our discovery opens new possibilities to explore what other molecules are involved in generating senescence: a goal we consider important if we want to design therapies that turn malignant tumors into benign tumors," Ferbeyre said. The research was published on January 1, 2011 in Genes and Development, and received funding from the Canadian Cancer Society and by the Fonds de la recherche en Santé du Québec.
http://www.sciencedaily.com/releases/2011/01/110106070908.htm 一、生物医药:文件类型:DOC/Microsoft Word- 文字版研制开发治疗恶性肿瘤的新药. 血液系统肿瘤(如白血病等)的发病率、死亡率逐年上升,... 为病人和医生跟踪治疗进展,监测癌细胞对药物的反应,及实施新的治疗方案提供科学依据. ...www.fjrs.gov.cn/...0576345.doc-2010-11-11-医药:" 中国神经时讯文件类型:PDF/Adobe Acrobat- 文字版的是找出良性脑膜瘤复发及 转为非典型和恶性组织学类 型的临床特征. 方法:对1965到... 救治和预后的重要因素. l 科学判断伤情,动态跟踪观察 对颅脑伤伤情的准确判断,是制定...www.qilu-pharma.com/...x08.pdf-2010-09-11-项目简编 (二)427个项目文件类型:DOC/Microsoft Word- 文字版36-049 BIO-K1药物分子在治疗耐药性恶性卵巢肿瘤的研究 生物医药 融资 我公司这项... 通过研发新型智能数据自动管理和分析技术给生命科学和生物医学研究人员提供前所未有...www.xsrs.gov.cn/...9161655.doc-2010-09-29-[标签:content2]
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作者:admin@医学,生命科学 2011-01-07 15:09
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