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【bio-news】SCI:力学因素成为生命活动调控者
Sci. Signal., 11 March 2008
Soluble growth factors are potent regulators of normal and pathological processes.Mechanical factors are emerging as similarly important, but there has been no obvious mechanism linking the different factors.A recent report now demonstrates that cell-generated mechanical tension results in release of active transforming growth factor–β from stiff extracellular matrix, providing a mechanism for differentiation and maintenance of myofibroblasts in processes like fibrosis. More broadly, the work suggests that matrix stiffness could regulate the equilibrium between storage and release of a host of matrix-bound growth factors.
Matrix Elasticity, Cytoskeletal Tension, and TGF-β: The Insoluble and Soluble Meet
基质弹性，细胞骨架张力和TGF-β：当不可溶和可溶性物质相见
Sci. Signal., 11 March 2008科学，信号版，08.3.11
可溶性生长因子，是生物正常及病理过程强有力的监管机构。力学因素正在成为同样重要的调控者，但其不同因素之间一直没有发现明显的连接机制。在最近发布的一份报告中显示，细胞产生的机械张力导致活性转化生长因子TGF-β从胞外基质中释放，这就阐明了纤维化等过程中肌成纤维细胞分化和维持的机制。更广泛的说，这暗示着，基质的刚度可能调控着大量基质结合型成纤维细胞生长因子的储存和释放平衡。
已索取到原文，但是上传没有成功，文件超过300K，需要者可以留下通信方式 elasticity: 弹性
mechanical factors: 力学因素
stiffness: 刚度
jzwk wrote:
elasticity: 弹性
mechanical factors: 力学因素
stiffness: 刚度
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[讨论] 运动因素成为生命活动调控者
http://www.tiyuol.com/viewthread.php?tid=5154&extra=page%3D1&frombbs=1 非常感兴趣,
楼主,给我一份全文好吗? liuying54609@126.com, 谢谢.liutcy wrote:
介绍一个允许上传文件较大的网站，请继续讨论：
[讨论] 运动因素成为生命活动调控者
http://www.tiyuol.com/viewthread.php?tid=5154&extra=page%3D1&frombbs=1
liuying54609 wrote:
非常感兴趣,
楼主,给我一份全文好吗? liuying54609@126.com, 谢谢.
能否给我传一份，很需要！
rfshi@hotmail.com,先谢谢！阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-10-22 13:09
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