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【medical-news】检测血中髓过氧化物酶水平可预测
Blood test signals heart disease in healthy people
Monday, July 2, 2007
NEW YORK (Reuters Health) - Measuring levels of an enzyme called myeloperoxidase in the blood may help predict whether apparently healthy individuals are likely to develop coronary artery disease in the future, according to a new report.
Previous reports have shown myeloperoxidase levels to be directly related to the likelihood of serious problems in patients with chest pain or suspected coronary disease, the authors explain in the Journal of the American College of Cardiology.
The focus of the present study was to see if levels of the enzyme could foretell problems for apparently healthy people. To that end, Dr. Matthijs Boekholdt, from the Academic Medical Center in Amsterdam, the Netherlands, and colleagues compared initial levels of myeloperoxidase in 1138 healthy subjects who developed coronary disease during 8 years of follow-up and 2237 matched "controls" who did not.
People with the highest myeloperoxidase levels had a 36 percent increased risk of coronary disease than those with the lowest levels, the researchers found.
In fact, myeloperoxidase levels were useful in predicting coronary disease even when cholesterol levels were normal.
"It is clear that elevation of inflammatory markers, such as myeloperoxidase ... precede the onset of coronary artery disease by years," the team concludes. This suggests that strategies aimed at lowering inflammation might help ward of heart disease.
SOURCE: Journal of the American College of Cardiology, July 10, 2007. 本人已认领该文编译，如48小时未能提交译文，请其他战友自由认领 Blood test signals heart disease in healthy people
Monday, July 2, 2007
检测血中髓过氧化物酶水平可预测冠心病
NEW YORK (Reuters Health) - Measuring levels of an enzyme called myeloperoxidase in the blood may help predict whether apparently healthy individuals are likely to develop coronary artery disease in the future, according to a new report.
一项新的研究报告称，检测血液中髓过氧化物酶的水平，将有助于预测表面健康个体未来是否可能发生冠心病。
Previous reports have shown myeloperoxidase levels to be directly related to the likelihood of serious problems in patients with chest pain or suspected coronary disease, the authors explain in the Journal of the American College of Cardiology.
此前的研究已经表明，髓过氧化物酶水平与胸痛或疑似冠心病患者出现严重症状的可能性具有直接的相关性。作者解释道。《美国心脏病学会杂志》
The focus of the present study was to see if levels of the enzyme could foretell problems for apparently healthy people. To that end, Dr. Matthijs Boekholdt, from the Academic Medical Center in Amsterdam, the Netherlands, and colleagues compared initial levels of myeloperoxidase in 1138 healthy subjects who developed coronary disease during 8 years of follow-up and 2237 matched "controls" who did not.
本研究集中研究了该酶水平是否可以预测表面健康人群疾病发生情况。为此，荷兰阿姆斯特丹学术医学中心的Matthijs Boekholdt博士及其同事对在8年随访期间发生冠心病的1138名健康者和没有发生冠心病的2237名匹配“对照者”最初的髓过氧化物酶水平进行了比较。
People with the highest myeloperoxidase levels had a 36 percent increased risk of coronary disease than those with the lowest levels, the researchers found.
研究发现，髓过氧化物酶水平最高者与最低者相比，发生冠心病的风险增加36%。
In fact, myeloperoxidase levels were useful in predicting coronary disease even when cholesterol levels were normal.
事实上，当胆固醇水平正常的情况下，髓过氧化物酶水平对于预测冠心病的发生大有裨益。
"It is clear that elevation of inflammatory markers, such as myeloperoxidase ... precede the onset of coronary artery disease by years," the team concludes. This suggests that strategies aimed at lowering inflammation might help ward of heart disease.
“很显然，诸如髓过氧化物酶之类的炎性标记物的水平在冠心病发作数年之前就有所升高。”研究小组总结说。这提示针对减少炎症的策略可有助于预防心脏疾病。
编译：
路透社报道，荷兰科学家一项新的研究表明，检测血液中髓过氧化物酶的水平，将有助于预测表面健康人群未来是否发生冠心病的可能。
研究人员称，此前的研究已经表明，髓过氧化物酶水平与胸痛或疑似冠心病患者出现严重症状的可能性具有直接的相关性。而此次研究着重考察了该酶水平是否可以预测表面健康人群未来疾病发生的可能性。为此，研究人员对在8年随访期间发生冠心病的1138名健康者和没有发生冠心病的2237名“对照者”最初的髓过氧化物酶水平进行了比较。结果发现，髓过氧化物酶水平最高者与最低者相比，冠心病发生风险增加36%。研究人员指出，事实上，在胆固醇水平正常的情况下，检测髓过氧化物酶水平对于预测冠心病的发生大有裨益。
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作者:admin@医学,生命科学 2011-02-18 17:11
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