主页 > 医学文档 >
【文摘发布】TGFβ在神经胶质瘤发生中的作用
Author：Alejandra Bruna, Rachel S. Darken, Federico Rojo, Alberto Ocaña, Silvia Peñuelas, Alexandra Arias, Raquel Paris, Avelina Tortosa, Jaume Mora, Jose Baselga, et al.
Resource：Cancer Cell. 2007 Feb;11(2):147-60.
Impact Factor：18.7 (2005)
Summary：TGFβ acts as a tumor suppressor in normal epithelial cells and early-stage tumors and becomes an oncogenic factor in advanced tumors. The molecular mechanisms involved in the malignant function of TGFβ are not fully elucidated. We demonstrate that high TGFβ-Smad activity is present in aggressive, highly proliferative gliomas and confers poor prognosis in patients with glioma. We discern the mechanisms and molecular determinants of the TGFβ oncogenic response with a transcriptomic approach and by analyzing primary cultured patient-derived gliomas and human glioma biopsies. The TGFβ-Smad pathway promotes proliferation through the induction of PDGF-B in gliomas with an unmethylated PDGF-B gene. The epigenetic regulation of the PDGF-B gene dictates whether TGFβ acts as an oncogenic factor inducing PDGF-B and proliferation in human glioma.
PMID：17292826 本人已认领该文，48小时后若未提交译文，请其他战友自由认领。 Title：High TGFβ-Smad Activity Confers Poor Prognosis in Glioma Patients and Promotes Cell Proliferation Depending on the Methylation of the PDGF-B Gene
题目：高β型转化生长因子（TGFβ）Smad基因活性对神经胶质瘤病人意味着不良的预后和依赖于血小板来源的生长因子B（PDGF-B）基因甲基化而刺激细胞增生
Author：Alejandra Bruna, Rachel S. Darken, Federico Rojo, Alberto Oca?a, Silvia Pe?uelas, Alexandra Arias, Raquel Paris, Avelina Tortosa, Jaume Mora, Jose Baselga, et al.
作者：Alejandra Bruna, Rachel S. Darken, Federico Rojo, Alberto Oca?a, Silvia Pe?uelas, Alexandra Arias, Raquel Paris, Avelina Tortosa, Jaume Mora, Jose Baselga,等。
Resource：Cancer Cell. 2007 Feb;11(2):147-60.
来源：Cancer Cell. 2007 Feb;11(2):147-60.
Impact Factor：18.7 (2005)
影响因子：18.7（2005）
Summary：TGFβ acts as a tumor suppressor in normal epithelial cells and early-stage tumors and becomes an oncogenic factor in advanced tumors. The molecular
mechanisms involved in the malignant function of TGFβ are not fully elucidated. We demonstrate that high TGFβ-Smad activity is present in aggressive, highly proliferative gliomas and confers poor prognosis in patients with glioma.
摘要：TGFβ在正常表皮细胞和早期肿瘤中是一种肿瘤抑制剂，在晚期肿瘤中变成一种致癌因子。恶性肿瘤中的TGFβ作用的分子机制尚未被完全阐明。我们证明高TGFβ-Smad基因活性存在于侵袭性和高增生性的神经胶质瘤中，并预示着患者不良的预后。
We discern the mechanisms and molecular determinants of the TGFβ oncogenic response with a transcriptomic approach and by analyzing primary cultured patient-derived gliomas and human glioma biopsies. The TGFβ-Smad pathway promotes proliferation through the induction of PDGF-B in gliomas with an unmethylated PDGF-B gene.
我们应用转录组学途径分析了TGFβ致癌反应的机制和分子决定性，并且分析了来源于神经胶质瘤病人的初级培养物和人类神经胶质瘤的活组织检查。TGFβ-Smad基因路径通过未甲基化的PDGF-B基因诱导神经胶质瘤中的PDGF-B而刺激增生。
The epigenetic regulation of the PDGF-B gene dictates whether TGFβ acts as an oncogenic factor inducing PDGF-B and proliferation in human glioma.
PDGF-B基因后续的调节指令TGFβ是否成为人类神经胶质瘤中诱导PDGF-B和增生的致癌因子。
PMID：17292826 题目：高β型转化生长因子（TGFβ）Smad基因活性对神经胶质瘤病人意味着不良的预后和依赖于血小板来源的生长因子B（PDGF-B）基因甲基化而刺激细胞增生
作者：Alejandra Bruna, Rachel S. Darken, Federico Rojo, Alberto Oca?a, Silvia Pe?uelas, Alexandra Arias, Raquel Paris, Avelina Tortosa, Jaume Mora, Jose Baselga,等。
Resource：Cancer Cell. 2007 Feb;11(2):147-60.
来源：Cancer Cell. 2007 Feb;11(2):147-60.
影响因子：18.7（2005）
摘要：TGFβ在正常表皮细胞和早期肿瘤中是一种肿瘤抑制剂，在晚期肿瘤中变成一种致癌因子。恶性肿瘤中的TGFβ作用的分子机制尚未被完全阐明。我们证明高TGFβ-Smad基因活性存在于侵袭性和高增生性的神经胶质瘤中，并预示着患者不良的预后。
我们应用转录组学途径分析了TGFβ致癌反应的机制和分子决定性，并且分析了来源于神经胶质瘤病人的初级培养物和人类神经胶质瘤的活组织检查。TGFβ-Smad基因路径通过未甲基化的PDGF-B基因诱导神经胶质瘤中的PDGF-B而刺激增生。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-18 12:59
医学,生命科学网