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【文摘发布】预防糖尿病的口服胰岛素的新研究
2007，10，16
New Study to Test Oral Insulin in the Prevention of Diabetes
预防糖尿病的口服胰岛素的新研究
TORONTO, Oct. 16, 2007 (Canada NewsWire via COMTEX) -- Researchers at The Hospital for Sick Children (SickKids) are leading the Canadian component of a multinational clinical study aimed at preventing or delaying type 1 diabetes. The Type 1 Diabetes TrialNet study will examine whether taking insulin orally can prevent or delay diabetes in people who are at risk for the disease.
2007，10，16，多伦多（加拿大新闻热线）儿童疾病医院的研究人员，正在领导多民族组成的加拿大人的临床研究，旨在预防或延缓1型糖尿病。这个1型糖尿病的TrialNet研究，将调查口服胰岛素是否能使有这种疾病的危险的人们得到预防或延缓
"People who have a first- or second-degree relative with type 1 diabetes have approximately a 15 times greater risk of developing the disease than the general population," says Dr. Diane Wherrett, staff endocrinologist at SickKids and the lead Canadian investigator for the Type 1 Diabetes TrialNet study for oral insulin. "Our goal is to determine whether taking oral insulin can help prevent type 1 diabetes or delay it, even for a few years, allowing those at risk a chance to avoid the challenges of controlling glucose levels and other serious health complications."
儿童医院的内分泌专家和 TrialNet研究的领导Diane Wherrett说“与1型糖尿病有主要关系和次要关系的人们比一般人群发生糖尿病 的危险将近大15倍，我们的目的是口服胰岛素是否有助于预防或延缓1型糖尿病，即使只有很少几年，让有危险的人们不会受到，控制葡萄糖水平和其他严重并发症的挑战，“
Type 1 diabetes, usually diagnosed in children, is due to abnormal autoimmunity that destroys insulin producing cells in the pancreas. Insulin is an essential hormone that allows the body's cells to use sugar for energy. Approximately 200,000 Canadians have type 1 diabetes and require daily insulin injections. Type 1 diabetes hardens small blood vessels and is the leading cause of blindness, kidney failure, stroke and loss of limbs.
1型糖尿病，常见于儿童，由于异常的自身免疫破坏了胰腺的细胞生产胰岛素，胰岛素是一种重要的激素，让身体细胞利用糖供应能量，将近20万加拿大人患1型糖尿病，需要每天注射胰岛素。1型糖尿病使小血管硬化，是失明，肾衰竭，中风和截肢的主要原因。
In this study, researchers will test whether an insulin capsule taken by mouth once a day can prevent or delay diabetes in a specific group of people at risk for type 1 diabetes. Some scientists believe that introducing insulin via the digestive track induces tolerance or a quieting of the immune system's destruction of cells that produce insulin. In a previous diabetes prevention trial using oral insulin, a sub-group showed a delay in the onset of type 1 diabetes.
本研究，研究人员将试验，用胰岛素胶囊一天口服一次，是否在有1型糖尿病危险的特殊人群中预防或延缓该疾病。一些科学家认为，引用的胰岛素通过消化道诱发耐受性，或者降低产生胰岛素细胞的免疫系统的破坏。以前一项口服胰岛素的糖尿病预防试验中，有一组显示1型糖尿病延缓发病
Approximately 20,000 people per year worldwide who have first- and second-degree relatives with type 1 diabetes will be recruited for the oral insulin study over the next five years. Individuals who are between the ages of three and 45 and have a first-degree blood relative (child, parent or sibling) or individuals who are between the ages of three and 20 and have a second-degree blood relative (uncle, aunt, niece, nephew, cousin or grandparent) with type 1 diabetes may be eligible for screening to determine their risk of developing this disease. The initial screening involves a single blood test to look for autoantibodies that may present long before the onset of diabetes. To enroll in the study or for more information, Canadians can call 416-813-5858 or 1-866-699-1899 or www.diabetestrialnet.org.
今后5年，全世界每年将有大约两万和1型糖尿病有主要和次要关系的人，参加口服胰岛素研究。年龄3岁到45岁之间主要血缘关系（孩子，父母或同胞兄妹）或者年龄3岁到20岁之间的次要血缘关系（叔叔，姑姑，姨妈，侄儿侄女，堂兄妹，表兄妹，或祖父母）于1型糖尿病有联系的人，都有资格遴选以确定发生糖尿病的危险。最初的筛选包括个别的血液检测，寻找糖尿病发生以前早已长期存在的自身抗体。参加这项研究或需要更多信息，加拿大人可电话416-813-5858 or 1-866-699-1899 或浏览www.diabetestrialnet.org.
The national study is led by SickKids, who will coordinate the trial with 10 other centres across Canada: Calgary, Edmonton, Vancouver, Winnipeg, Saint John, St. John's, Halifax, Hamilton, London and Montreal.
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作者:admin@医学,生命科学 2011-06-03 17:11
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