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【drug-news】硫酸软骨素的抗炎活性
Summary
Osteoarthritis is primarily characterized by areas of destruction of articular cartilage and by synovitis. Articular damage and synovitis are secondary to local increase of pro-inflammatory cytokines (interleukin-1β and tumor necrosis factor-α), enzymes with proteolytic activity (matrix metalloproteinases), and enzymes with pro-inflammatory activity (cyclooxygenase-2 and nitric oxide synthase-2). Enhanced expression of these proteins in chondrocytes and in synovial membrane appears associated to the activation and nuclear translocation of nuclear factor-κB (NF-κ. Chondroitin sulfate (CS) prevents joint space narrowing and reduces joint swelling and effusion. To produce these effects, CS elicits an anti-inflammatory effect at the chondral and synovial levels. CS and its disaccharides reduce NF-κB nuclear translocation, probably by diminishing extracellular signal-regulated kinase1/2, p38mitogen-activated protein kinase and c-Jun N-terminal kinase activation. This review discusses the evidence supporting that CS pleiotropic effects in chondrocytes and synoviocytes are primarily due to a common mechanism, e.g., the inhibition of NF-κB nuclear translocation.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WD9-4T5HJ57-2&_user=10&_coverDate=08%2F08%2F2008&_rdoc=1&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236761%239999%23999999999%2399999%23FLA%23display%23Articles)&_cdi=6761&_sort=d&_docanchor=&_ct=8&_version=1&_urlVersion=0&_userid=10&md5=15e2018c54b809027d78fcc946a5b6f0 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Anti-inflammatory activity of chondroitin sulfate
抗炎活性硫酸软骨素
Summary
综述
Osteoarthritis is primarily characterized by areas of destruction of articular cartilage and by synovitis. Articular damage and synovitis are secondary to local increase of pro-inflammatory cytokines (interleukin-1β and tumor necrosis factor-α), enzymes with proteolytic activity (matrix metalloproteinases), and enzymes with pro-inflammatory activity (cyclooxygenase-2 and nitric oxide synthase-2). Enhanced expression of these proteins in chondrocytes and in synovial membrane appears associated to the activation and nuclear translocation of nuclear factor-κB (NF-κ. Chondroitin sulfate (CS) prevents joint space narrowing and reduces joint swelling and effusion. To produce these effects, CS elicits an anti-inflammatory effect at the chondral and synovial levels. CS and its disaccharides reduce NF-κB nuclear translocation, probably by diminishing extracellular signal-regulated kinase1/2, p38mitogen-activated protein kinase and c-Jun N-terminal kinase activation. This review discusses the evidence supporting that CS pleiotropic effects in chondrocytes and synoviocytes are primarily due to a common mechanism, e.g., the inhibition of NF-κB nuclear translocation
骨性关节炎的主要特点是地区的破坏关节软骨和结节性滑膜炎。关节损伤和结节性滑膜炎是次要的地方增加了前炎症细胞因子（白细胞介素- 1β和肿瘤坏死因子- α ） ，与蛋白水解酶的活性（基质金属蛋白酶） ，以及酶与亲炎症活动（环氧合酶-2和一氧化氮合酶-2 ） 。增强表达这些蛋白质在细胞和滑膜出现相关的活化和核易位核因子- κB （ NF-κ.硫酸软骨素（ CS ）的防止关节空间缩小，并减少关节肿胀和积液。产生这些影响，政务司司长引起了抗炎作用的软骨和关节的水平。政务司司长和糖减少NF - κB的核转，很可能通过减少细胞外信号调节激酶/ 2 ， p38mitogen活化蛋白激酶和c - Jun N -末端激酶激活。本次审查讨论的证据支持这一政务司司长多效影响软骨和滑膜主要是由于一个共同的机制，如抑制NF - κB的核转 抗炎活性硫酸软骨素
综述
骨性关节炎的主要特点是地区的破坏关节软骨和结节性滑膜炎。关节损伤和结节性滑膜炎是次要的地方增加了前炎症细胞因子（白细胞介素- 1β和肿瘤坏死因子- α ） ，与蛋白水解酶的活性（基质金属蛋白酶） ，以及酶与亲炎症活动（环氧合酶-2和一氧化氮合酶-2 ） 。增强表达这些蛋白质在细胞和滑膜出现相关的活化和核易位核因子- κB （ NF-κ.硫酸软骨素（ CS ）的防止关节空间缩小，并减少关节肿胀和积液。产生这些影响，政务司司长引起了抗炎作用的软骨和关节的水平。政务司司长和糖减少NF - κB的核转，很可能通过减少细胞外信号调节激酶/ 2 ， p38mitogen活化蛋白激酶和c - Jun N -末端激酶激活。本次审查讨论的证据支持这一政务司司长多效影响软骨和滑膜主要是由于一个共同的机制，如抑制NF - κB的核转 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-05-30 19:24
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