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【bio-news】红酒心脏保护作用又有新线索
Wed Nov 29, 2006 3:26pm ET
NEW YORK (Reuters Health) - Scientists in the UK have identified "oligomeric procyanidins" as the likely ingredient in red wine's polyphenols that contributes to heart health and longevity. And some red wines contain more procyanidins than others.
In the journal Nature, Dr. Roger Corder, from Queen Mary's School of Medicine and Dentistry in London, and his associates note that not everyone agrees that red wine actually possess heart-healthy properties, which they say may be due to the complexity and variability in the constituents in different wines.
To look into this issue, the investigators cultured human blood vessel cells and exposed them to 165 different wines to identify the polyphenols with most potent effects on blood vessels.
They found that procyanidins suppress production of a protein called endothelin-1 that constricts blood vessels. High-performance liquid chromatography identified oligomeric procyanidins as the specific phenolic constituent responsible for this effect.
People living in Nuoro province, Sardinia, and southwest France have higher than normal average longevity. And wines from those regions, Corder and colleagues found, had a 2- to 4-fold higher inhibitory effect on endothelin-1 and significantly higher oligomeric procyanidin levels than wines from Australia, Europe, South America, the US, and Sardinia.
Corder and his associates maintain that traditional wine-making methods and use of the flavonoid-rich grape Tannat commonly grown in southwest France result in high levels of oligomeric procyanidins in the local wine.
The researchers are hopeful that further investigation of oligomeric procyanidins-rich wines and foods will provide insight into how blood vessel function might be optimally maintained.
SOURCE: Nature, November 30, 2006.
http://today.reuters.com/news/articlenews.aspx?type=healthNews&storyID=2006-11-29T202610Z_01_COL973457_RTRUKOC_0_US-RED-WINE.xml&WTmodLoc=HealthNewsHome_C2_healthNews-6 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 New clue to red wine's heart-protecting effect
Wed Nov 29, 2006 3:26pm ET
红酒保护心脏作用新线索
NEW YORK (Reuters Health) - Scientists in the UK have identified "oligomeric procyanidins" as the likely ingredient in red wine's polyphenols that contributes to heart health and longevity. And some red wines contain more procyanidins than others.
纽约（路透社健康版）——英国科学家已经鉴别出 “前氰定低聚物”是红酒多酚类的主要成分，对心脏健康长寿起作用。并且，某些红酒比其他红酒含更多的前氰定。
In the journal Nature, Dr. Roger Corder, from Queen Mary's School of Medicine and Dentistry in London, and his associates note that not everyone agrees that red wine actually possess heart-healthy properties, which they say may be due to the complexity and variability in the constituents in different wines.
在《自然》杂志上，伦敦玛丽女皇医学和口腔学院的Roger Corder博士及他的助手指出并不是所有人赞同红酒实际上能够保护心脏健康，这可能取决于不同红酒成分的复杂程度和多样性。
To look into this issue, the investigators cultured human blood vessel cells and exposed them to 165 different wines to identify the polyphenols with most potent effects on blood vessels.
为了深入了解这个问题，研究者培养了人血管内皮细胞并将它们分别与165种不同的红酒接触，来鉴别对血管最有效的多酚类。
They found that procyanidins suppress production of a protein called endothelin-1 that constricts blood vessels. High-performance liquid chromatography identified oligomeric procyanidins as the specific phenolic constituent responsible for this effect.
他们发现前氰定抑制称为内皮素-1的蛋白质的产生，其能够使血管收缩。高效液相层析鉴别出前氰定低聚物为产生上述作用的特异性酚类成分。
People living in Nuoro province, Sardinia, and southwest France have higher than normal average longevity. And wines from those regions, Corder and colleagues found, had a 2- to 4-fold higher inhibitory effect on endothelin-1 and significantly higher oligomeric procyanidin levels than wines from Australia, Europe, South America, the US, and Sardinia.
在Sardinia ，Nuoro省及法国西南部的居民寿命较正常平均寿命高。与来自澳大利亚、欧洲、南美、美国以及Sardinia的红酒相比较，Corder及其同事发现在这些地区生产的酒对内皮素-1的抑制作用为2-4倍并且明显含有高水平的前氰定低聚物。
Corder and his associates maintain that traditional wine-making methods and use of the flavonoid-rich grape Tannat commonly grown in southwest France result in high levels of oligomeric procyanidins in the local wine.
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作者:admin@医学,生命科学 2011-06-02 05:14
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