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【medical-news】肠道CT可以对克隆氏病对严重程度进
NEW YORK (Reuters Health), Nov 7 - Quantitative measures of bowel image enhancement at computed tomography (CT) enterography correlate with endoscopic and histological severity of ileal Crohn's disease, Minnesota-based researchers report in the November issue of Gut. Associations are also seen with C-reactive protein levels.
As lead investigator Dr. Joel G. Fletcher told Reuters Health, "because Crohn's disease is an inflammatory disease involving the small bowel, and because recent technical innovations permit faster and higher resolution CT scanning, modern CT scanners are now able to detect and measure inflammation involving and surrounding the small bowel wall."
To investigate such relationships, Dr. Fletcher and colleagues at the Mayo Clinic College of Medicine in Rochester, MN, studied CT enterography datasets from 143 patients undergoing ileoscopy.
Endoscopic severity score was significantly correlated with CT bowel enhancement, vascular enlargement of the vasa recta, and mesenteric fat density. Correlations with histological inflammation were strongest for bowel enhancement.
Compared with patients with increased bowel enhancement alone, serum C-reactive protein was significantly elevated in those with increased fat density -- an indicator of extraintestinal inflammation.
C-reactive protein did not correlate with inflammation limited to the small bowel wall, underscoring "the potential role of perienteric inflammation in C-reactive protein response to Crohn's disease." Further experiments, they add, "are needed to explore the mechanism linking C-reactive protein with mesenteric vascularity and fat."
In the future, concluded Dr. Fletcher, "we hope to quantitate Crohn's disease inflammation at imaging and combine this information with other markers to give gastroenterologists and surgeons a true idea of the inflammatory disease burden and type in every Crohn's patient."
Last Updated: 2006-11-06 15:53:03 -0400 (Reuters Health) CT enterography can determine Crohn's disease severity
NEW YORK (Reuters Health), Nov 7 - Quantitative measures of bowel image enhancement at computed tomography (CT) enterography correlate with endoscopic and histological severity of ileal Crohn's disease, Minnesota-based researchers report in the November issue of Gut. Associations are also seen with C-reactive protein levels.
肠道CT增强检查的影像学定量测量结果与内镜和组织学上对回肠克隆氏病对分级具有相关性，并且与C反应蛋白水平之间也有相关性。Minnesota的研究人员的这一成果发表在11月份的《胃肠》杂志上，并且
As lead investigator Dr. Joel G. Fletcher told Reuters Health, "because Crohn's disease is an inflammatory disease involving the small bowel, and because recent technical innovations permit faster and higher resolution CT scanning, modern CT scanners are now able to detect and measure inflammation involving and surrounding the small bowel wall."
Joel Fletcher 告诉路透社说：因为克隆氏病是一炎性病变，主要累及小肠，最近的影像学技术发展，CT分辨力更高，扫描速度更快，现在的CT机器可以检测肠壁及肠壁周围的炎症。
To investigate such relationships, Dr. Fletcher and colleagues at the Mayo Clinic College of Medicine in Rochester, MN, studied CT enterography datasets from 143 patients undergoing ileoscopy.
为了寻找这一相关关系，Fletcher和Rochester医学院Mayo医院的研究人员一起分析了143例进行回肠镜检查的病例。
Endoscopic severity score was significantly correlated with CT bowel enhancement, vascular enlargement of the vasa recta, and mesenteric fat density. Correlations with histological inflammation were strongest for bowel enhancement.
内窥镜评分严重程度与CT的肠壁强化程度、肠系膜动脉扩张程度、肠系膜脂肪密度具有明显相关，组织病理学上的炎症与强化程度之间的相关最强。
Compared with patients with increased bowel enhancement alone, serum C-reactive protein was significantly elevated in those with increased fat density -- an indicator of extraintestinal inflammation.
对于那些只有肠壁明显强化的病人，病人血清C反应蛋白明显增高，肠系膜脂肪密度也增加，提示肠外炎症。
C-reactive protein did not correlate with inflammation limited to the small bowel wall, underscoring "the potential role of perienteric inflammation in C-reactive protein response to Crohn's disease." Further experiments, they add, "are needed to explore the mechanism linking C-reactive protein with mesenteric vascularity and fat."
对于仅限于肠壁的炎症，C反应蛋白与炎症没有相关性，研究人员说：“克隆氏病中C反应蛋白增加中，肠周炎症扮演的角色不明，需要进一步探讨c反应蛋白与肠系膜动脉和脂肪之间关系的机制。
In the future, concluded Dr. Fletcher, "we hope to quantitate Crohn's disease inflammation at imaging and combine this information with other markers to give gastroenterologists and surgeons a true idea of the inflammatory disease burden and type in every Crohn's patient."
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作者:admin@医学,生命科学 2011-06-02 05:11
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