主页 > 医学新闻 >
【medical-news】Avastin破坏脑室屏障引发致命颅脑感
New research by scientists at Schepens Eye Research Institute may help explain why the anti-cancer drug Avastin, which targets a growth factor responsible for creation of new blood vessels, causes potentially fatal brain inflammation in certain patients. Institute scientists mimicked the drug's activity in mice and found that it damaged the cell lining that prevents fluid from leaking from the ventricle into the brain. The ventricle is the structure in the brain that holds cerebral spinal fluid after it is produced and which is continuous with the spinal cord.
"This finding is significant because it may ultimately modify the way we use systemic drugs that block blood vessel growth, and it also suggests that VEGF (vascular endothelial growth factor) plays a more extensive role in the body than we previously thought," says Dr. Patricia D'Amore, senior scientist at Schepens Eye Research Institute and principal investigator of the study.
The cancer drug Avastin (bevacizumab) is used to treat advanced bowel cancer in combination with chemotherapy. By targeting VEGF, Avastin inhibits the growth of tumors by cutting off their blood supply and thus depriving them of oxygen and other nutrients. In a small percentage of patients, however, Avastin can cause neurological side effects, ranging from headaches and blurry vision to potentially fatal seizures and brain swelling.
D'Amore and her team found that VEGF normally protects the specialized cells that create a seal between the brain and ventricle and thus prevent fluid from leaking into the brain. When VEGF was blocked in mice, these cells were damaged and the animals developed brain lesions. The authors suspect that Avastin's side effects in humans may be caused by a similar phenomenon. Why these symptoms occur in only a few patients is not yet known.
The results are currently published online (on February 11th) in The Journal of Experimental Medicine.
Authors of the study include Arindel S.R. Maharaj*,2,3, Tony E. Walshe*,2,3, Magali Saint-Geniez2,3, Shivalingappa Venkatesha2,4, Angel E. Maldonado2,3, Nathan C. Himes2, Kabir S. Matharu3, S. Ananth Karumanchi2,4 and Patricia A. D'Amore1,2,3
Author affiliations: 1Departments of Ophthalmology and Pathology, 2Harvard Medical School, 3Schepens Eye Research Institute, 4Center for Vascular Biology, Departments of Medicine, Obstetrics, Gynecology, Surgery and Pathology, Beth Israel Deaconess Medical Center.
http://www.sciencedaily.com/releases/2008/02/080213095631.htm 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 New research by scientists at Schepens Eye Research Institute may help explain why the anti-cancer drug Avastin, which targets a growth factor responsible for creation of new blood vessels, causes potentially fatal brain inflammation in certain patients. Institute scientists mimicked the drug's activity in mice and found that it damaged the cell lining that prevents fluid from leaking from the ventricle into the brain. The ventricle is the structure in the brain that holds cerebral spinal fluid after it is produced and which is continuous with the spinal cord.
Schepens Eye研究所的科学家们的一项新研究有助于解释为何抗抑制促进新生血管的生长因子的抗癌药物Avastin,，在一些患者中能导致潜在的致命的脑部炎症。研究所的科学家们用小鼠模拟此药的活性，发现Avastin可损害细胞系。该细胞系起着阻断脑室向脑组织流动的渗液。脑室是脑内脑脊液产生并持续保存，与脊髓相连续的结构。
"This finding is significant because it may ultimately modify the way we use systemic drugs that block blood vessel growth, and it also suggests that VEGF (vascular endothelial growth factor) plays a more extensive role in the body than we previously thought," says Dr. Patricia D'Amore, senior scientist at Schepens Eye Research Institute and principal investigator of the study.
“这项发现很重要。因为这可以最终修改我们用系统性药物阻断血管生长的方法，并且也暗示VEGF（血管生长因子）在体内所起的广泛作用超出我们先前考虑到的” Schepens Eye研究所的资深科学家、首席研究者Patricia D'Amore博士说。
The cancer drug Avastin (bevacizumab) is used to treat advanced bowel cancer in combination with chemotherapy. By targeting VEGF, Avastin inhibits the growth of tumors by cutting off their blood supply and thus depriving them of oxygen and other nutrients. In a small percentage of patients, however, Avastin can cause neurological side effects, ranging from headaches and blurry vision to potentially fatal seizures and brain swelling.
癌症药物Avastin（贝伐单抗）在联合化疗中用于治疗高分化肠癌。Avastin通过靶向作用于血管内皮生长因子，断绝血液供应而阻止肿瘤生长，因而剥夺肿瘤的氧和其它营养供应。但在一小部分患者中，Avastin可导致神经的副反应，从头痛和视物模糊到潜在的致命的癫痫发作和脑肿胀。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-05-27 17:14
医学,生命科学网