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【drug-news】伟哥或许可帮助服用抗忧郁症药物妇
July 23, 2008, 8:11 am
Viagra May Ease Sexual Problems of Women on Antidepressants
Posted by Jacob Goldstein
For both men and women, sexual problems are a common side effect of antidepressants. Viagra and similar drugs have long been prescribed to men in this situation. Now a study suggests Viagra may help women as well.
ViagraThe study looked at 98 premenopausal women with major depression who started to have sexual problems after going on a popular class of antidepressants that includes drugs such as Zoloft and Prozac. The women were randomly assigned to receive either Viagra or a placebo for eight weeks.
The researchers, based the University of New Mexico School of Medicine and other institutions, evaluated the women on a standard scale that ranges from 1 (normal function) to 7 (most extreme sexual dysfunction).
Those who received Viagra went from 4.8 before they started taking the drug to 2.8 eight weeks later, on average. That was a significantly larger average improvement than the placebo group, which went from 4.7 to 3.6. Some side effects, such as flushing and congestion, were more common among those who received Viagra.
The study was funded by Pfizer, which the researchers said played no role in the design or conduct of the project. The results are published in JAMA this week.
Viagra has not been approved for use in women, and Pfizer gave up on pursuing that FDA approval after studies of the drug in women failed to show a benefit.
But the new results could prompt doctors to prescribe Viagra off-label for premenopausal women whose sexual problems began after they went on antidepressants. “This will change practice,” Andrew Leuchter, a professor of psychiatry at UCLA who was not involved in the study, told the Los Angeles Times. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 July 23, 2008, 8:11 am
Viagra May Ease Sexual Problems of Women on Antidepressants
Posted by Jacob Goldstein
2008年7月23日，上午8：11
伟哥或许能够减轻服用抗抑郁药物妇女的性功能障碍
据雅各·古德斯坦说。
For both men and women, sexual problems are a common side effect of antidepressants. Viagra and similar drugs have long been prescribed to men in this situation. Now a study suggests Viagra may help women as well.
性功能障碍是抗抑郁药物常见的不良反应，与性别无关。在此种情况下，伟哥及同类的药物用于男性已有很长时间，目前有研究提示伟哥对女性有同样作用。
ViagraThe study looked at 98 premenopausal women with major depression who started to have sexual problems after going on a popular class of antidepressants that includes drugs such as Zoloft and Prozac. The women were randomly assigned to receive either Viagra or a placebo for eight weeks.
对98个绝经前的患有严重抑郁症的的妇女进行研究，结果显示，她们在服用大众化类抗抑郁药（包括如舍曲林与氟西汀）后开始出现性功能障碍。她们被随机分为两组，分别服用伟哥与安慰剂，持续八周。
The researchers, based the University of New Mexico School of Medicine and other institutions, evaluated the women on a standard scale that ranges from 1 (normal function) to 7 (most extreme sexual dysfunction).
来自新墨西哥州医药大学和其他研究所的研究员们，将性功能状况从1度（性功能正常）到7度（性功能极度障碍）分为7个等级，并以此标准评价这些妇女的性功能状况。
Those who received Viagra went from 4.8 before they started taking the drug to 2.8 eight weeks later, on average. That was a significantly larger average improvement than the placebo group, which went from 4.7 to 3.6. Some side effects, such as flushing and congestion, were more common among those who received Viagra.
8周后，伟哥组从服药前的4.8平均下降至2.8，与对照组（从服药前的4.7平均下降至3.6）相比，其性功能得到明显改善，但另一些不良反应，如面红跟充血，较对照组也更为明显。
The study was funded by Pfizer, which the researchers said played no role in the design or conduct of the project. The results are published in JAMA this week.
这项研究的资金来源于辉瑞公司，据研究员们称，辉瑞公司没有参与该项研究的设计与进行。这项成果于本周在JAMA上发表了。
Viagra has not been approved for use in women, and Pfizer gave up on pursuing that FDA approval after studies of the drug in women failed to show a benefit.
伟哥没有被批准用于女性，而辉瑞公司在发现这项研究无利可图之后也放弃了争取FDA的批准。
But the new results could prompt doctors to prescribe Viagra off-label for premenopausal women whose sexual problems began after they went on antidepressants. “This will change practice,” Andrew Leuchter, a professor of psychiatry at UCLA who was not involved in the study, told the Los Angeles Times.
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作者:admin@医学,生命科学 2011-04-29 14:41
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