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【bio-news】细胞杂志发表综述评论: 干细胞与早期
Janet Rossant1,*
1Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Department of Molecular Genetics, University
of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
*Correspondence: janet.rossant@sickkids.ca
DOI 10.1016/j.cell.2008.01.039
The recent derivation of pluripotent stem cell lines from a number of different sources, including reprogrammed adult somatic cells, raises the issue of the developmental equivalence of these different pluripotent states. At least two different states representing the epiblast progenitors in the blastocyst and the pluripotent progenitors of the later gastrulating embryo have been recognized. Understanding the initial developmental status of the different pluripotent lines is critical for defining starting conditions for differentiation toward therapeutically relevant cell types.
http://download.cell.com/pdfs/0092-8674/PIIS0092867408001402.pdf 本人认领此文 Janet Rossant1,*
1Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Department of Molecular Genetics, University
of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
*Correspondence: janet.rossant@sickkids.ca
DOI 10.1016/j.cell.2008.01.039
The recent derivation of pluripotent stem cell lines from a number of different sources, including reprogrammed adult somatic cells, raises the issue of the developmental equivalence of these different pluripotent states.
近年来包括由重编成体细胞等不同来源获得的多潜能干细胞,引出了对这些不同多潜能状态的发育均等性的问题。
At least two different states representing the epiblast progenitors in the blastocyst and the pluripotent progenitors of the later gastrulating embryo have been recognized.
最少两种代表不同的发育状态已得到确认，一种是胚泡中的外胚层祖细胞，另一种为晚期原胚多潜能祖细胞。
Understanding the initial developmental status of the different pluripotent lines is critical for defining starting conditions for differentiation toward therapeutically relevant cell types.
弄清这些不同多潜能细胞系的初始发育状态对于制定使其向治疗相关细胞类型分化时的起始条件是非常关键的。 近年来包括由重编成体细胞等不同来源获得的多潜能干细胞,引出了对这些不同多潜能状态的发育均等性的问题。最少两种代表不同的发育状态已得到确认，一种是胚泡中的外胚层祖细胞，另一种为晚期原胚多潜能祖细胞。弄清这些不同多潜能细胞系的初始发育状态对于制定使其向治疗相关细胞类型分化时的起始条件是非常关键的。 。。。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-22 21:09
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