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【文摘发布】静脉注射脑源性神经营养因子可促
Author：Schäbitz WR, Steigleder T, Cooper-Kuhn CM, Schwab S, Sommer C, Schneider A, Kuhn HG.
From the Department of Neurology, University of Münster, Germany; the Department of Neurology, University of Erlangen, Germany; the Department of Neuropathology, University of Mainz, Germany; Sygnis Pharma, Heidelberg, Germany; and the Institute for Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Resource: Stroke. 2007 May 17; [Epub ahead of print]
Abstract：BACKGROUND AND PURPOSE: The discovery of spontaneous neuronal replacement in the adult brain has shifted experimental stroke therapies toward a combined approach of preventing neuronal cell death and inducing neuronal plasticity. Brain-derived neurotrophic factor (BDNF) was shown to induce antiapoptotic mechanisms after stroke and to reduce infarct size and secondary neuronal cell death. Moreover, in intact animals, BDNF is a potent stimulator of adult neurogenesis. METHODS: The current study analyzed the effects of BDNF on induction of neuronal progenitor cell migration and sensorimotor recovery after cortical photothrombotic stroke. RESULTS: Daily intravenous bolus applications of BDNF during the first 5 days after stroke resulted in significantly improved sensorimotor scores up to 6 weeks. At the structural level, BDNF significantly increased neurogenesis in the dentate gyrus and enhanced migration of subventricular zone progenitor cells to the nearby striatum of the ischemic hemisphere. BDNF treatment could not, however, further stimulate progenitor cell recruitment to the cortex. CONCLUSIONS: These findings consolidate the role of BDNF as a modulator of neurogenesis in the brain and as an enhancer of long-term functional neurological outcome after cerebral ischemia.
PMID: 17510456
大家都知道，神经内科在治疗上的进步远跟不上其在诊断上的发展，这篇文章也许能给我们一点希望？ 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 初译：
Title：Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis.
静脉注射脑源性神经营养因子可促进卒中后感觉运动的恢复和刺激神经发生
Author：Schäbitz WR, Steigleder T, Cooper-Kuhn CM, Schwab S, Sommer C, Schneider A, Kuhn HG.
From the Department of Neurology, University of Münster, Germany; the Department of Neurology, University of Erlangen, Germany; the Department of Neuropathology, University of Mainz, Germany; Sygnis Pharma, Heidelberg, Germany; and the Institute for Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Resource: Stroke. 2007 May 17; [Epub ahead of print]
Abstract：摘要：
BACKGROUND AND PURPOSE: The discovery of spontaneous neuronal replacement in the adult brain has shifted experimental stroke therapies toward a combined approach of preventing neuronal cell death and inducing neuronal plasticity. Brain-derived neurotrophic factor (BDNF) was shown to induce antiapoptotic mechanisms after stroke and to reduce infarct size and secondary neuronal cell death. Moreover, in intact animals, BDNF is a potent stimulator of adult neurogenesis.
背景和目的：在成人大脑中自主神经替代的发现将试验性卒中治疗转换到联用疗法预防神经细胞死亡以及诱导神经适应。脑源性神经营养因子(BDNF)被显示了卒中后可诱导抗凋亡机制并减少梗塞面积以及继发神经细胞死亡。此外，在正常动物中，BDNF对于成人的神经发生是一种潜在的刺激质。 结果部分，应该是5天吧
呵呵
刚开始一看5年，把我吓一跳，哪来那么多钱注射？
谍影重重 wrote:
初译：
Title：Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis.
静脉注射脑源性神经营养因子可促进卒中后感觉运动的恢复和刺激神经发生
Author：Schäbitz WR, Steigleder T, Cooper-Kuhn CM, Schwab S, Sommer C, Schneider A, Kuhn HG.
From the Department of Neurology, University of Münster, Germany; the Department of Neurology, University of Erlangen, Germany; the Department of Neuropathology, University of Mainz, Germany; Sygnis Pharma, Heidelberg, Germany; and the Institute for Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Resource: Stroke. 2007 May 17; [Epub ahead of print]
Abstract：摘要：
BACKGROUND AND PURPOSE: The discovery of spontaneous neuronal replacement in the adult brain has shifted experimental stroke therapies toward a combined approach of preventing neuronal cell death and inducing neuronal plasticity. Brain-derived neurotrophic factor (BDNF) was shown to induce antiapoptotic mechanisms after stroke and to reduce infarct size and secondary neuronal cell death. Moreover, in intact animals, BDNF is a potent stimulator of adult neurogenesis.阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-26 05:11
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