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【medical-news】HIV感染最早期即可被阻止？
ScienceDaily (Feb. 28, 2008) — Researchers at The Scripps Research Institute have developed a new two-punch strategy against HIV and they have already successfully tested aspects of it in the laboratory.
Their study, which appears in the online Early Edition of the Proceedings of the National Academy of Sciences, may re-energize attempts to create a preventive/therapeutic vaccine against HIV, say the authors. To date, more than a dozen candidate vaccines, which have attempted to raise immunity against the spiky proteins on the viral envelope, have all failed in clinical testing.
The investigators have created devices they call glycodendrons that are designed to do two things at once: inhibit the transport of HIV from where it traditionally enters the body, preventing it from moving deeper inside where it can infect immune cells; and set up an immune antibody response to a unique carbohydrate structure on the surface of the virus.
"This paper is about a new direction in HIV vaccine design," said the study's lead investigator, Scripps Research Chemistry Professor Chi-Huey Wong. "Results we have so far are very promising."
To date, he says the devices have been able to stimulate the immune system of mice to induce antibodies against HIV surface glycoprotein, and, in laboratory studies, have been able to block the virus from infecting immune cells.
Targeting One Multi-Purpose Area on HIV 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 New Approach Stops HIV At Earliest Stage Of Infection
HIV感染早期阻断新途径
ScienceDaily (Feb. 28, 2008) — Researchers at The Scripps Research Institute have developed a new two-punch strategy against HIV and they have already successfully tested aspects of it in the laboratory.
ScienceDaily（2008-2-28）为了对抗HIV，Scripps的研究人员已经提出了一种新的策略，并且他们已经在实验室的成功的完成了验证。
Their study, which appears in the online Early Edition of the Proceedings of the National Academy of Sciences, may re-energize attempts to create a preventive/therapeutic vaccine against HIV, say the authors. To date, more than a dozen candidate vaccines, which have attempted to raise immunity against the spiky proteins on the viral envelope, have all failed in clinical testing.
研究者称，这项刚刚发表于国家科学院学报网络版的最新研究会再次鼓舞人们去开发对抗HIV的预防性或者治疗性的疫苗。至今为止，超过十几种试图提高对HIV病毒包膜上的蛋白免疫反应的候选疫苗在临床试验中均已宣告失败。
The investigators have created devices they call glycodendrons that are designed to do two things at once: inhibit the transport of HIV from where it traditionally enters the body, preventing it from moving deeper inside where it can infect immune cells; and set up an immune antibody response to a unique carbohydrate structure on the surface of the virus.
研究人员创造性地成功开发了一种被他们称为“glycodendrons”的方法，它会立刻产生两种效应：1、阻止HIV从常见的感染部位进入人体深部，那样会感染免疫细胞；2、刺激产生针对病毒表面糖类的特异性抗体。
"This paper is about a new direction in HIV vaccine design," said the study's lead investigator, Scripps Research Chemistry Professor Chi-Huey Wong. "Results we have so far are very promising."
这项研究的领导者，Scripps研究所化学教授Chi-Huey Wong说：“这项研究为HIV疫苗设计提供了一个新的方向，目前我们得到的结果令人充满希望。”
To date, he says the devices have been able to stimulate the immune system of mice to induce antibodies against HIV surface glycoprotein, and, in laboratory studies, have been able to block the virus from infecting immune cells.
他还说，目前为止的结果显示，这种方法可以刺激小鼠的免疫系统，并诱导产生对抗HIV表面糖蛋白的抗体，从而阻止病毒感染免疫细胞。
Targeting One Multi-Purpose Area on HIV
HIV的一个多功能区作为靶目标
This new approach capitalizes on two recent findings in the field of HIV research. One is the discovery that HIV takes a Trojan horse approach to reach cells it needs to infect deep inside the human body. Scientists have described how, when the virus enters the body through sexual contact, it hitches a ride with the dendritic cells of the immune system that stand guard for invaders at the mucosal lining of tissues.
这种新方法利用了两项最近艾滋病毒研究领域的结果。一项是HIV通过木马程序来到达它要感染的人体细胞。科学家们描述道，当病毒通过性接触进入人体，它就粘附到免疫系统的树突状细胞上，这种细胞存在于组织粘膜内层起保护作用。
The virus outsmarts these cells, however, and latches onto a particular receptor protein, known as DC-SIGN, on the dendritic cells. By sticking to these immune system fighters, HIV manages to evades immune detection while the dendritic cells travel to the ultimate goal of the virus: immune T-Cells in the lymphoid system, which HIV then invades, setting up a deadly infection that spreads.
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作者:admin@医学,生命科学 2011-04-19 05:14
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