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【medical-news】研究人员发现了过敏性疾病与自身
Researchers Discover Connection Between Allergic Diseases And Autoimmune Diseases
Article Date: 06 Apr 2007 - 3:00 PDT
A new study by researchers at Children's Hospital and Regional Medical Center and the University of Washington (UW) identifies a connection between allergic diseases such as atopic dermatitis, also known as eczema, and autoimmune diseases. The study was published in the April 1 edition of Nature Immunology.
Approximately 75 percent of autoimmune diseases occur in women, most frequently during the childbearing years. These diseases also comprise a significant portion of chronic childhood disorders. Autoimmune disease refers to a group of more than 80 serious, chronic illnesses including diseases of the nervous, gastrointestinal, and endocrine systems as well as skin and other connective tissues, eyes, blood, and blood vessel. In all of these diseases, the underlying problem is similar--the body's immune system (including B and/or T immune cells) becomes misdirected, attacking the very organs it was designed to protect.
"Our study implies that allergic and inflammatory diseases may actually trigger autoimmune diseases by relaxing the controls that normally eliminate newly produced, self-reactive B cells. This is important because many autoimmune diseases are caused by self-reactive antibodies produced by such B cells" said Dr. David Rawlings lead researcher and section head of Immunology at Children's Hospital and the UW.
Researchers at Children's are now trying to discover specifically where the "relaxation" in the control of B cell autoimmunity takes place. "In association with other UW laboratories, we also have begun to study drugs that can counter some of these effects. One such drug helps to prevent autoimmune kidney disease in a related animal model," said Rawlings. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Researchers Discover Connection Between Allergic Diseases And Autoimmune Diseases
研究人员发现了过敏性疾病与自身免疫性疾病之间的联系
Article Date: 06 Apr 2007 - 3:00 PDT
文章发表日期：太平洋夏令时2007年4月6日，3：00
A new study by researchers at Children's Hospital and Regional Medical Center and the University of Washington (UW) identifies a connection between allergic diseases such as atopic dermatitis, also known as eczema, and autoimmune diseases. The study was published in the April 1 edition of Nature Immunology.
在儿童医院、区域医疗中心及华盛顿大学(UW) 的研究人员进行的一项新研究确定了过敏性疾病如过敏性皮炎（也称为湿疹）与自身免疫性疾病之间的联系。这项研究刊登在月1日版的《自然∙免疫学》杂志上。
Approximately 75 percent of autoimmune diseases occur in women, most frequently during the childbearing years. These diseases also comprise a significant portion of chronic childhood disorders. Autoimmune disease refers to a group of more than 80 serious, chronic illnesses including diseases of the nervous, gastrointestinal, and endocrine systems as well as skin and other connective tissues, eyes, blood, and blood vessel. In all of these diseases, the underlying problem is similar--the body's immune system (including B and/or T immune cells) becomes misdirected, attacking the very organs it was designed to protect.
大约75%的自身免疫性疾病发生在妇女身上,并且最常在生育年龄阶段。 这些疾病的一个重要组成部分，也是慢性童年期紊乱。自身免疫性疾病是指一组超过80多种严重的慢性疾病包括神经系统疾病、胃肠道疾病、内分泌系统疾病以及皮肤和结缔组织、眼睛、血液、血管疾病。 在所有这些疾病中潜在问题是相似的--人体免疫系统(包括B和/或T免疫细胞)被误导，攻击起它本应保护的自身器官来。
"Our study implies that allergic and inflammatory diseases may actually trigger autoimmune diseases by relaxing the controls that normally eliminate newly produced, self-reactive B cells. This is important because many autoimmune diseases are caused by self-reactive antibodies produced by such B cells" said Dr. David Rawlings lead researcher and section head of Immunology at Children's Hospital and the UW.
“我们的研究暗示,过敏性及炎症疾病可能通过放松（正常情况下是清除）对新产生的自反应B细胞的控制引发了自身免疫性疾病，这是很重要的，因为许多自身免疫性疾病都是由这种B细胞产生的抗体引起的”首席研究员、儿童医院与华盛顿大学免疫学组长David Rawlings博士说。
Researchers at Children's are now trying to discover specifically where the "relaxation" in the control of B cell autoimmunity takes place. "In association with other UW laboratories, we also have begun to study drugs that can counter some of these effects. One such drug helps to prevent autoimmune kidney disease in a related animal model," said Rawlings.
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作者:admin@医学,生命科学 2011-04-25 05:11
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