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【medical-news】高体重指数增加帕金森病风险
NEW YORK (Reuters Health) Dec 20 - The results of a study published in the December issue of Neurology suggest an association between high body mass index (BMI) and an increased risk of Parkinson's disease in middle-age women and men.
"In recent years, two prospective studies have assessed the association between obesity and the risk of Parkinson's disease, but the results are inconsistent," Dr. Gang Hu, of the National Public Health Institute, Helsinki, and colleagues note.
To further investigate, the researchers examined the association between BMI and the risk of Parkinson's disease in 22,367 Finnish men and 23,439 women between the ages of 25 and 59 years without Parkinson's disease at baseline. Cox proportional hazards models were used to estimate hazard ratios (HRs) of incident PD for different levels of BMI.
Over a mean of 18.8 years, 272 men and 254 women developed incident Parkinson's disease. The mean age at diagnosis was 62.6 years and 64.3 years in men and women, respectively. The overall incidence of Parkinson's disease was higher in men than women, but Parkinson's disease increased with age for both sexes.
After adjustment for confounding factors, the HRs of Parkinson's disease for men with a BMI of less than 23, 23 to 24.9, 25 to 26.9, 27 to 29.9, and 30 or greater were 1.00, 1.97, 1.83, 2.34, and 2.44.
For women, the corresponding HRs were 1.00, 1.50, 1.65, 1.79 and 1.77.
In men and women combined, the HRs were 1.00, 1.70, 1.70, 2.02, and 2.03.
A direct association between BMI and Parkinson's disease risk was found in subjects between 25 and 59 years old and also in never smokers and smokers; and patients diagnosed with Parkinson's disease before or after 65 years of age.
The mechanisms behind the association between obesity and Parkinson's disease risk are unclear. Dopamine has been reported to play a role in the regulation of food intake. "A recent study showed that obese individuals have a lower dopamine D2 receptor availability in the striatum than that in normal weight individuals, which may lead to eating disorders and obesity," Dr. Hu and colleagues suggest.
"The decrements in dopamine D2 receptors in obese individuals might represent a downregulation to compensate for dopamine increase, which may induce oxidative stress and dopaminergic neuron death, as suggested in one study."
http://www.medscape.com/viewarticle/549688 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 High BMI Increases Risk of Parkinson's Disease
高体重指数增加帕金森病风险
NEW YORK (Reuters Health) Dec 20 - The results of a study published in the December issue of Neurology suggest an association between high body mass index (BMI) and an increased risk of Parkinson's disease in middle-age women and men.
纽约(路透社健康)12月20日 - 发表于12月刊《神经学》杂志的一项研究显示，中年女性和男性患帕金森病的风险与高体重指数(BMI)之间存在关联。
"In recent years, two prospective studies have assessed the association between obesity and the risk of Parkinson's disease, but the results are inconsistent," Dr. Gang Hu, of the National Public Health Institute, Helsinki, and colleagues note.
国家公共卫生研究所（NPHI）的胡刚（音），赫尔辛基及其同事指出，"近年来,有两项前瞻性研究对肥胖症和帕金森病风险之间的联系进行了评估，但各自得出的结果却不尽一致",
To further investigate, the researchers examined the association between BMI and the risk of Parkinson's disease in 22,367 Finnish men and 23,439 women between the ages of 25 and 59 years without Parkinson's disease at baseline. Cox proportional hazards models were used to estimate hazard ratios (HRs) of incident PD for different levels of BMI.
为更进一步了解这种联系， 研究人员调查了年龄层在25 ～59 岁之间的基线分数提示无帕金森病的22，367名芬兰男子和23，439名妇女。应用Cox模型（Cox proportional hazards model）评估高体重指数（BMI）处于不同水平时的帕金森病发病风险比率(HRs)。
Over a mean of 18.8 years, 272 men and 254 women developed incident Parkinson's disease. The mean age at diagnosis was 62.6 years and 64.3 years in men and women, respectively. The overall incidence of Parkinson's disease was higher in men than women, but Parkinson's disease increased with age for both sexes.
272个男人和254个妇女患有帕金森病，病程平均超过18.8 年。男性的平均诊断年龄是62.6 ，而女性则是64.3 岁。与女性相比较，男性的帕金森病总发病率较高，但是不论男女，帕金森病的发病率均随年龄增长而增加。
After adjustment for confounding factors, the HRs of Parkinson's disease for men with a BMI of less than 23, 23 to 24.9, 25 to 26.9, 27 to 29.9, and 30 or greater were 1.00, 1.97, 1.83, 2.34, and 2.44.
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作者:admin@医学,生命科学 2011-04-19 17:14
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