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【medical-news】down综合征儿童白血病与医学检查中
12/4/2006
By: Reuters Health
NEW YORK (Reuters Health), Dec 4 - The heightened risk for leukemia in children with Down syndrome does not appear to be related to ionizing radiation exposure associated with medical testing, researchers with the Children's Oncology Group report in the November issue of Pediatrics
The incidence of leukemia among Down syndrome children is 10- to 20-fold higher than in children without Down syndrome.
"Leukemia in children with Down syndrome is likely multifactorial and it is thought that the trisomy is likely the first in a series of genetic 'hits,'" Dr. Julie A. Ross and Amy M. Linabery of the University of Minnesota, Minneapolis, told Reuters Health. "The current study was undertaken as it was hypothesized that x-ray irradiation may be one of these environmental hits."
The Children's Oncology Group studied 158 children with Down syndrome and leukemia and 173 children with Down syndrome without leukemia, who served as controls. Of the cases, 97 children had acute lymphoblastic leukemia and 61 children had acute myeloid leukemia.
Radiation exposure before conception, in utero and postnatally was assessed.
Dr. Ross and Linabery told Reuters Health that "this study failed to find a moderate to large effect of diagnostic x-ray irradiation in the etiology of leukemia among children with Down syndrome."
"The lack of a strong association between postnatal medical test exposure and acute leukemia among children with Down syndrome should be reassuring for physicians, as well as concerned parents, as these children are subjected to diagnostic irradiation in the course of their standard primary care," the investigators commented.
"Caution should be exercised in interpreting these results, as this is the first study to investigate this association among this patient population," they advised. "Future studies should include greater sample sizes as well as more precise methods of dose evaluation."
By Martha Kerr
Last Updated: 2006-12-01 14:22:24 -0400 (Reuters Health)
http://www.auntminnie.com/index.asp?Sec=sup&Sub=xra&Pag=dis&ItemId=73855 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Leukemia in Down syndrome children not linked to medical test irradiation
12/4/2006
By: Reuters Health
Down综合症儿童患白血病和医学检查辐射无关。 12/4/2006 路透社健康栏目
NEW YORK (Reuters Health), Dec 4 - The heightened risk for leukemia in children with Down syndrome does not appear to be related to ionizing radiation exposure associated with medical testing, researchers with the Children's Oncology Group report in the November issue of Pediatrics
纽约（路透社健康专栏），12月4日：在患有Down综合症的儿童中，白血病发病率高和医学检查中的电离辐射无关。儿童肿瘤研究组的研究人员在11月的儿科杂志上这样报道。
The incidence of leukemia among Down syndrome children is 10- to 20-fold higher than in children without Down syndrome.
在Down综合症儿童中，白血病的发病率是无Down综合症儿童的10－20倍。
"Leukemia in children with Down syndrome is likely multifactorial and it is thought that the trisomy is likely the first in a series of genetic 'hits,'" Dr. Julie A. Ross and Amy M. Linabery of the University of Minnesota, Minneapolis, told Reuters Health. "The current study was undertaken as it was hypothesized that x-ray irradiation may be one of these environmental hits."
患有Down综合症的儿童并发白血病的原因可能是一个多因素的，有人认为三体本身可能就是基因打击的第一阶段。位于明尼阿波利斯州明尼苏达大学的Julie A博士和amy M博士告诉路透社健康栏目，目前的研究主要是基于这样的假设：X线辐射可能是这些多因素中的之一。
The Children's Oncology Group studied 158 children with Down syndrome and leukemia and 173 children with Down syndrome without leukemia, who served as controls. Of the cases, 97 children had acute lymphoblastic leukemia and 61 children had acute myeloid leukemia.
儿童肿瘤组织对比研究了158名患有Down综合症以及白血病的儿童和173名仅患有Down综合症而没有白血病的儿童(作为对照)，在158名研究病例中，有97名是急性淋巴细胞白血病和61名急性髓细胞白血病。
Radiation exposure before conception, in utero and postnatally was assessed.
分别检测了在受孕、子宫中以及生后的放射情况。
Dr. Ross and Linabery told Reuters Health that "this study failed to find a moderate to large effect of diagnostic x-ray irradiation in the etiology of leukemia among children with Down syndrome."
Ross博士和他的同道告诉路透社健康栏目：这个研究没有发现中等到大剂量的诊断性X线辐射对Down综合症儿童发生白血病有明显的作用。
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作者:admin@医学,生命科学 2011-04-22 21:07
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