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【Nature Immunology 编译】上皮细胞和树突状细胞共
Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells
来源
Nature Immunology 6, 507 - 514 (2005)
Published online: 10 April 2005; | doi:10.1038/ni1192
http://www.nature.com/ni/journal/v6/n5/abs/ni1192.html
原文摘要
The control of damaging inflammation by the mucosal immune system in response to commensal and harmful ingested bacteria is unknown. Here we show epithelial cells conditioned mucosal dendritic cells through the constitutive release of thymic stromal lymphopoietin and other mediators, resulting in the induction of 'noninflammatory' dendritic cells. Epithelial cell−conditioned dendritic cells released interleukins 10 and 6 but not interleukin 12, and they promoted the polarization of T cells toward a 'classical' noninflammatory T helper type 2 response, even after exposure to a T helper type 1−inducing pathogen. This control of immune responses seemed to be lost in patients with Crohn disease. Thus, the intimate interplay between intestinal epithelial cells and dendritic cells may help to maintain gut immune homeostasis.
编译
粘膜免疫系统对栖生的和通过有害摄入而进入体内的细菌的免疫反应可引起机体的炎症损伤，到目前为止，机体对这类损伤控制的机制还不清楚。我们的研究发现，上皮细胞通过释放胸腺基质细胞分泌的淋巴细胞生成素组分和其它介质来调节粘膜树突状细胞，诱导产生非炎性的树突状细胞。上皮细胞调节树突状细胞产生白细胞介素10和6，但不产生白细胞介素12。它们能促使T细胞极化为“经典”的非炎性TH2辅助细胞，即使是暴露于TH1辅助细胞介导的病原。在患克罗恩病的病人身上看不到这种对免疫反应的控制。所以，肠上皮细胞和树突状细胞之间的密切的相互作用有助于维持消化道内的免疫稳态。 dear maomaoyu ,能否把这篇文章的全文贴出来，谢谢 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-19 17:14
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