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【文摘发布】叶酸可降低脑卒中风险
Author: Prof Xiaobin Wang MD , Xianhui Qin MS , Hakan Demirtas PhD , et al
Resource:The Lancet 2007; 369:1876-1882
ABSTRACT
Background
The efficacy of treatments that lower homocysteine concentrations in reducing the risk of cardiovascular disease remains controversial. Our aim was to do a meta-analysis of relevant randomised trials to assess the efficacy of folic acid supplementation in the prevention of stroke.
Methods
We collected data from eight randomised trials of folic acid that had stroke reported as one of the endpoints. Relative risk (RR) was used as a measure of the effect of folic acid supplementation on the risk of stroke with a random effect model. The analysis was further stratified by factors that could affect the treatment effects.
Findings
Folic acid supplementation significantly reduced the risk of stroke by 18% (RR 0·82, 95% CI 0·68–1·00; p=0·045). In the stratified analyses, a greater beneficial effect was seen in those trials with a treatment duration of more than 36 months (0·71, 0·57–0·87; p=0·001), a decrease in the concentration of homocysteine of more than 20% (0·77, 0·63–0·94; p=0·012), no fortification or partly fortified grain (0·75, 0·62–0·91; p=0·003), and no history of stroke (0·75, 0·62–0·90; p=0·002). In the corresponding comparison groups, the estimated RRs were attenuated and insignificant.
Interpretation
Our findings indicate that folic acid supplementation can effectively reduce the risk of stroke in primary prevention. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 http://www.dxy.cn/bbs/post/view?bid=116&id=9204726&sty=1&tpg=1&age=0 重复 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-15 05:11
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