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SARS基因组突变与其他冠状病毒不同
have resulted in the sequencing of the genome of the
causative agent of severe acute respiratory syndrome
(SARS), novel coronavirus SARS-CoV, in record time.
Using cumulative skew diagrams, I found that mutational
patterns in the SARS-CoV genome were strikingly
different from other coronaviruses in terms of
mutation rates, although they were in general agreement
with the model of the coronavirus lifecycle. These
findings might be relevant for the development of
sequence-based diagnostics and the design of agents
to treat SARS.
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Mutational patterns correlate with genome
organization in SARS and other coronaviruses
Andrei Grigoriev
GPC Biotech, Fraunhoferstr. 20, Martinsried 82152, Germany [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-05 05:20
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