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【medical-news】过去三十年多发性骨髓瘤的存活率
NEW YORK (Reuters Health) Jun 21 - Survival of patients with multiple myeloma has improved significantly during the last three decades, investigators in Sweden report.
Dr. Magnus Bjorkholm, of Karolinska University Hospital in Stockholm, and colleagues have published their findings in the May issue of the Journal of Clinical Oncology.
The researchers conducted a large population-based cohort study to define patterns of survival among patients with multiple myeloma diagnosed during a 30-year period in Sweden.
A total of 14,381 patients (7643 males and 6738 females) diagnosed between 1973 and 2003 were included in the study. The mean patient age was 69.9 years old. The team used relative survival ratio (RSR) as a measure of patient survival.
There was a significant improvement in 1-year survival in all age groups. The 1-year RSRs increased from 0.73 between 1973 and1979 to 0.82 between 1994 and 2003.
Improvement in 5-year RSR was restricted to patients younger than 70 years at diagnosis, according to the authors.
Improvement in 10-year RSR was confined to patients younger than 60 years at diagnosis. "This was reflected further in a 29% lower 10-year excess mortality among multiple myeloma patients diagnosed from 1994 to 2003 compared with those diagnosed from 1987 to 1993," Dr. Bjorkholm's team reports.
Females had an overall 3% lower mortality than males.
The investigators note that factors that have probably contributed to improved survival are high-dose melphalan with subsequent autologous stem cell transplantation, thalidomide, and a continuous improvement in supportive care. However, they add, new effective and tolerable agents are needed to improve survival in older patients.
J Clin Oncol 2007;25:1993-1999.
https://profreg.medscape.com/px/getlogin.do?urlCache=aHR0cDovL3d3dy5tZWRzY2FwZS5jb20vdmlld2FydGljbGUvNTU4Njky 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Survival Has Improved in Multiple Myeloma Patients
多发性骨髓瘤病人的存活率有显著改善
NEW YORK (Reuters Health) Jun 21 - Survival of patients with multiple myeloma has improved significantly during the last
three decades, investigators in Sweden report.
纽约（路透通讯社 健康部）6.21－瑞典研究者报道过去三十年多发性骨髓瘤的存活率有显著改善。
Dr. Magnus Bjorkholm, of Karolinska University Hospital in Stockholm, and colleagues have published their findings in the
May issue of the Journal of Clinical Oncology.
斯德哥尔摩Karolinska大学医院的Magnus Bjorkholm医生和同事们已经在临床肿瘤杂志五月评论中发表了他们的发现。
The researchers conducted a large population-based cohort study to define patterns of survival among patients with
multiple myeloma diagnosed during a 30-year period in Sweden.
研究者进行了一项大人群的队列研究来解释瑞典30年间诊断为多发性骨髓瘤的患者的生存模式。
A total of 14,381 patients (7643 males and 6738 females) diagnosed between 1973 and 2003 were included in the study. The mean patient age was 69.9 years old. The team used relative survival ratio (RSR) as a measure of patient survival.
在1973至2003年间一共有14381例确诊病人（7643男性和6738女性）被纳入此研究。病人的平均年龄为69.9岁。研究团队将相对存活率作为病人生存的度量指标。
There was a significant improvement in 1-year survival in all age groups. The 1-year RSRs increased from 0.73 between 1973 and1979 to 0.82 between 1994 and 2003.
所有年龄组的一年生存率有显著改善。一年生存率由1973年到1979年间的0.73增长至1994年到1979年间的0.82。
Improvement in 5-year RSR was restricted to patients younger than 70 years at diagnosis, according to the authors.Improvement in 10-year RSR was confined to patients younger than 60 years at diagnosis.
研究表明，5年间相对生存率的改善仅限于70岁以前作出诊断的病人.10年间相对生存率的改善仅限于60岁以前作出诊断的病人.
"This was reflected further in a 29% lower 10-year excess mortality among multiple myeloma patients diagnosed from 1994to 2003 compared with those diagnosed from 1987 to 1993," Dr. Bjorkholm's team reports.
"更进一步表现在与1987年到1993年间诊断的病例相比较，1994到2003年间诊断的病例的10年死亡率要低29％。"Bjorkholm医生研究组报道。
Females had an overall 3% lower mortality than males.
女性的死亡率比男性患者低3％。
The investigators note that factors that have probably contributed to improved survival are high-dose melphalan with subsequent autologous stem cell transplantation, thalidomide, and a continuous improvement in supportive care.
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作者:admin@医学,生命科学 2011-03-04 05:11
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