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【medical-news】蚊子病毒或成疟疾治疗突破
AgDNV is a densonucleosis virus (densovirus) - a type common to mosquitoes and other insects but not infectious to humans and other vertebrates. The AgDNV virus does not actually harm mosquitoes, but researchers believe it is highly infectious to larvae and is easily passed to the adults.
Researcher Jason Rasgon, PhD (Johns Hopkins Bloomberg School of Public Health's Malaria Research Institute) notes that this new finding came about while the investigators were actually trying to use Wolbachia bacteria to infect An. gambiae mosquito cells. Co-author Xiaoxia Ren was analyzing the gel used to detect the bacteria when an "artifact" that appeared as an unexpected prominent band in the gel was noticed.
Ragson admits that, "Finding artifacts such as this one during experiments is not uncommon, but we decided to investigate this one further since we kept observing it over and over. When we sequenced it, we were surprised to learn that we had found a new virus."
The researchers believe that the virus can be altered to kill the mosquito or make it incapable of transmitting malaria. In order to test how much control the authors had over the virus, the altered the AgDNV so that adult mosquitoes presented a harmless green fluorescent protein that is spotted using a microscope.
"In theory, we could use this virus to produce a lethal toxin in the mosquito or instruct the mosquito to die after 10 days, which is before it can transmit the malaria parasite to humans. However, these concepts are many years away," concludes Rasgon. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Mosquitoes are known for transmitting deadly viruses to humans, but the insects themselves are susceptible to viral infection. According to a study published in the open-access journal PLoS Pathogens, researchers at Johns Hopkins University have described a virus that infects the mosquito best known for transmitting malaria - Anopheles gambiae. Malaria kills over one million people worldwide every year, and the researchers believe that the infectious mosquito virus might be used to control malaria by passing on new genetic information to A. gambiae.
众所周知，蚊子能向人类传播致死性病毒，但是他们自己也可被病毒感染。根据一项发表在可免费访问的期刊PLoS Pathogens上的研究，约翰霍普金斯大学的研究者已经描述了一种可以感染以传播疟疾出名的冈比亚按蚊的病毒。每年，疟疾在全世界导致一百多万人死亡，并且研究者们相信这种能感染蚊子的病毒可能通过传递新的基因信息给冈比亚按蚊而被用来控制疟疾。
AgDNV is a densonucleosis virus (densovirus) - a type common to mosquitoes and other insects but not infectious to humans and other vertebrates. The AgDNV virus does not actually harm mosquitoes, but researchers believe it is highly infectious to larvae and is easily passed to the adults.
AgDNV是一种齿状核增生病毒，易于感染蚊子和其他昆虫，但是对人类和其他脊椎动物却没有感染力。事实上，这种AgDNV病毒并不对蚊子造成伤害，但是研究者们认为这种病毒易于感染蚊子的幼虫并且容易传递给成虫。
Researcher Jason Rasgon, PhD (Johns Hopkins Bloomberg School of Public Health's Malaria Research Institute) notes that this new finding came about while the investigators were actually trying to use Wolbachia bacteria to infect An. gambiae mosquito cells. Co-author Xiaoxia Ren was analyzing the gel used to detect the bacteria when an "artifact" that appeared as an unexpected prominent band in the gel was noticed.
约翰霍普金斯大学公共卫生学院疟疾研究所的研究者Jason Rasgon博士谈到，正当研究者们试图用Wolbachia细菌感染冈比亚按蚊细胞时，这项新的发现出现了。合作者任小霞正在分析用来检测细菌的凝胶时，在凝胶上发现了一个意料之外的显著的条带。
Ragson admits that, "Finding artifacts such as this one during experiments is not uncommon, but we decided to investigate this one further since we kept observing it over and over. When we sequenced it, we were surprised to learn that we had found a new virus."
Ragson承认说：“在实验中发现这个条带并不是罕见的，但是我们决定进一步研究这个条带，因为我们一次又一次地观察到了它。当测定出它的基因序列后，我们吃惊地认识到我们已经发现了一种新的病毒。”
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作者:admin@医学,生命科学 2011-01-12 05:14
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