主页 > 医学文档 >
【medical-news】B型利钠肽新用途：感染性休克的诊
By Anthony J. Brown, MD
NEW YORK (Reuters Health) Mar 24 - B-type natriuretic peptide (BNP) appears to be a useful biomarker for diagnosis and risk stratification of patients with septic shock in the absence of congestive heart failure, US researchers report.
They note in the March issue of the Archives of Surgery that progression of sepsis leads to damage of cardiomyocytes and cardiac contractile dysfunction. Cardiovascular collapse is the main cause of death for the roughly 200,000 fatal cases of septic shock that occur each year in the US.
There is a need for an easy and reliable method of assessing cardiovascular dysfunction in patients with septic shock, Dr. Martin H. Bluth, from SUNY Downstate Medical Center in Brooklyn, New York, and colleagues contend.
"Although other studies have demonstrated BNP as a marker for sepsis and cardiac disease, this is the first study to investigate its use as a potential marker for pure sepsis. Patients with any evidence of cardiac disease were not included in this study," Dr. Bluth told Reuters Health.
The researchers' study involved a comparison of BNP levels in 13 patients with septic shock, 18 with early sepsis, and 18 healthy age-matched controls. All of the septic shock patients were free from heart or renal failure. The patients were followed for up to 21 days and sepsis severity was assessed using the Sequential Organ Failure Assessment (SOFA) scoring system.
Patients with septic shock, but not with early sepsis, had elevated BNP levels relative to controls (p < 0.05). Moreover, the BNP level was directly related to the SOFA score.
Among septic shock patients, a drop in BNP levels during follow-up was predictive of survival, whereas continuation of high levels correlated with death.
However, not everyone is convinced of the predictive value of BNP levels in patients with septic shock. Editorialist Dr. Eddie L. Hoover, from Buffalo VA Medical Center in New York, comments that the researchers provide no data to support their contention that the "BNP level may serve as 'a valuable measure for determining reduced left ventricular function in patients with septic shock'."
He adds that Dr. Bluth's team "can say only that if BNP levels remain high, death is imminent; there is little one can do with such information except withhold treatment, which is not an option in this context."
Dr. Bluth emphasized that "these studies are preliminary and further investigation is necessary before the utility and application of BNP in sepsis is clarified."
Arch Surg 2008;143:242-246.
http://www.medscape.com/viewarticle/571906 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 B-Type Natriuretic Peptide Predicts Severity of Sepsis
B型钠尿苔能预测感染严重程度
By Anthony J. Brown, MD
NEW YORK (Reuters Health) Mar 24 - B-type natriuretic peptide (BNP) appears to be a useful biomarker for diagnosis and risk stratification of patients with septic shock in the absence of congestive heart failure, US researchers report.
3月24日纽约（路透社健康部门）美国研究者报道：B型钠尿肽（BNP）似乎是无充血性心衰的感染性休克患者的诊断和危险分层的有用生物标记物。
They note in the March issue of the Archives of Surgery that progression of sepsis leads to damage of cardiomyocytes and cardiac contractile dysfunction. Cardiovascular collapse is the main cause of death for the roughly 200,000 fatal cases of septic shock that occur each year in the US.
他们在3月发行的手术档案的中记录，脓毒血症进展能导致心肌细胞损伤和心脏收缩性功能不全。在美国每年大概200，000例脓毒血症致死性病例中的主要是应为心血管事件。
There is a need for an easy and reliable method of assessing cardiovascular dysfunction in patients with septic shock, Dr. Martin H. Bluth, from SUNY Downstate Medical Center in Brooklyn, New York, and colleagues contend.
来自Downstate Medical Cente（Brooklyn，纽约）Martin H. Bluth博士以及同事说：有必要通过一简单和可靠的方法来评价感染性休克患者的心血管功能不全。
"Although other studies have demonstrated BNP as a marker for sepsis and cardiac disease, this is the first study to investigate its use as a potential marker for pure sepsis. Patients with any evidence of cardiac disease were not included in this study," Dr. Bluth told Reuters Health.
Bluth博士向路透社报道：虽然其他研究已经显示BNP为脓毒血症和心脏疾病的一标记物，这也是首次试验来研究BNP作为单纯脓毒血症的潜在标记物。有任何心脏疾病证据的患者将排出在此研究之外。
The researchers' study involved a comparison of BNP levels in 13 patients with septic shock, 18 with early sepsis, and 18 healthy age-matched controls. All of the septic shock patients were free from heart or renal failure. The patients were followed for up to 21 days and sepsis severity was assessed using the Sequential Organ Failure Assessment (SOFA) scoring system.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-01 05:14
医学,生命科学网