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【medical-news】产妇血清中胎盘蛋白13（PP13）水平
In the August issue of the American Journal of Obstetrics and Gynecology, Dr. Roberto Romero of Wayne State University/Hutzel Women's Hospital, Detroit, and colleagues note that in recent studies, reduced PP13, has been associated with a significantly increased risk of preeclampsia.
To determine if this protein would be useful in risk assessment, the researchers used data from a prospective study conducted in Chile including 50 women with preeclampsia and 250 with normal pregnancies.
Calculating the PP13 multiples of the median for gestational age, the team found that concentrations were significantly lower in mothers who developed preterm and early onset preeclampsia than in those with normal pregnancies.
The researchers found that PP13 did not identify mild preeclampsia at term and was only a weak marker of severe preeclampsia at term
"Because the lower concentration of PP13 is observed in the first trimester of pregnancy, months before the development of clinical disease," say the investigators, "this suggests that the decreased concentration in maternal blood is not the consequence of the disease."
Dr. Romero told Reuters Health that the results are promising, but stressed that larger studies are required. "In particular," he said, "a prospective study combining first trimester PP13 with other analytes and sonographic findings such as Doppler studies of the uterine arteries, might be helpful in the assessment of risk for the development of preeclampsia."
Am J Obstet Gynecol 2008;199:122.e1-122.e11. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 产妇血清中胎盘蛋白13（PP13）水平可预测早期先兆子痫发生风险
NEW YORK (Reuters Health) Sept 05 - Concentration of first-trimester maternal serum placental protein (PP) 13 is useful in determining the risk of early-onset preeclampsia.
纽约（路透社） 9月5日
第一孕期产妇血清中的胎盘蛋白（PP）13的浓度可以用来预测早期先兆子痫发生风险。
In the August issue of the American Journal of Obstetrics and Gynecology, Dr. Roberto Romero of Wayne State University/Hutzel Women's Hospital, Detroit, and colleagues note that in recent studies, reduced PP13, has been associated with a significantly increased risk of preeclampsia.
在8月份出版的美国杂志妇产科，韦恩州立大学的博士罗伯托罗梅罗/许策尔的妇女医院，底特律，和他的同事注意到，在最近的研究中，减少的PP13与先兆子痫的风险显着增加有关。
To determine if this protein would be useful in risk assessment, the researchers used data from a prospective study conducted in Chile including 50 women with preeclampsia and 250 with normal pregnancies.
为了判断这种蛋白质在风险评估是否有用，研究人员使用在智利进行的一个前瞻性研究的数据，其研究涉及了50名先兆子痫孕妇和250名正常怀孕的妇女。
Calculating the PP13 multiples of the median for gestational age, the team found that concentrations were significantly lower in mothers who developed preterm and early onset preeclampsia than in those with normal pregnancies.
该研究小组发现：根据不同胎龄，计算PP13的倍数，先兆子痫孕妇体内PP13的浓度明显低于那些与正常怀孕的孕妇。
The researchers found that PP13 did not identify mild preeclampsia at term and was only a weak marker of severe preeclampsia at term
研究人员发现，PP13不能指示轻度先兆子痫，并且对于严重的先兆子痫也只是一个比较弱的标志。
"Because the lower concentration of PP13 is observed in the first trimester of pregnancy, months before the development of clinical disease," say the investigators, "this suggests that the decreased concentration in maternal blood is not the consequence of the disease."
“因为低浓度的PP13是在第一孕期、临床疾病发展之前的几个月观察到的 ”调查人员说，“这表明，孕妇血清中PP13浓度的降低不是疾病引起的后果” 。
Dr. Romero told Reuters Health that the results are promising, but stressed that larger studies are required. "In particular," he said, "a prospective study combining first trimester PP13 with other analytes and sonographic findings such as Doppler studies of the uterine arteries, might be helpful in the assessment of risk for the development of preeclampsia."
罗梅罗博士告诉路透社：结果是另人憧憬的，但需要更多的研究。他说：“尤其是把前瞻性研究与第一孕期的PP13和其他组分相结合，并且像多普勒研究的子宫动脉的超音波检查结果可能对先兆子痫的风险评估会有所帮助。” 纽约（路透社） 9月5日
第一孕期产妇血清中的胎盘蛋白（PP）13的浓度可以用来预测早期先兆子痫发生风险。
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作者:admin@医学,生命科学 2010-10-13 17:11
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