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【medical-news】机制研究：氧化游离脂肪酸水平加
"It has long been suspected that lipid metabolism is involved in the pathogenesis of acute pancreatitis," Dr. Daniel Closa from Institut d'Investigacions Biomediques, Barcelona, told Reuters Health. "Our work indicates a mechanism of action for several lipids in the exacerbation of the systemic inflammatory response associated with this disease."
Dr. Closa and colleagues examined the effect of the lipid fraction of pancreatitis-associated ascitic fluid generated in the early stages of acute pancreatitis. The findings are published in the May issue of Gut.
High levels of thiobarbiturate acid reacting substances in the pancreatitis-associated ascitic fluid lipid extract indicated an intense oxidative alteration in the lipids contained in ascitic fluid, the investigators say.]
These lipids obtained from pancreatitis-associated ascitic fluid reduced cell viability of macrophages and hepatocytes by 70%, the authors report, whereas lipids from white adipose tissue had no effect on cell viability.
Injection of complete pancreatitis-associated ascitic fluid or purified lipids obtained from pancreatitis-associated ascitic fluid into the portal vein increased serum AST, reflecting hepatotoxicity, but had no effect on serum lipase, indicating a lack of deleterious action in the pancreas, the researchers note.
The pancreatitis-associated ascitic fluid lipid extract was shown to abolish the macrophage inhibitory activity of endogenous PPAR-gamma agonists, thereby promoting an exacerbation of macrophage activation, the report indicates.
"This research helps to explain the resistance of acute pancreatitis to treatment," Dr. Closa said. "The release of a strong pro-inflammatory stimulus generated by the pancreatic gland in combination with interferences in the regulatory mechanisms due to the presence of several oxidize lipids make this pathology a formidable challenge in clinical practice."
"Our finding could open new therapeutic strategies for the treatment of the inflammatory response in acute pancreatitis," Dr. Closa said. "The generation of oxidized lipids interferes with the physiological regulation of the inflammatory response. Acting on these lipids in order to restore the endogenous control of inflammation could be a promising therapeutic approach."
Gut 2008;57:642-648. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 NEW YORK (Reuters Health) May 28 - Oxidized free fatty acids in ascitic fluid promote an exacerbation of macrophage activation in acute pancreatitis.
纽约（Reuter Health）5月28日——腹水中的氧化的游离脂肪酸可以启动急性胰腺炎中巨噬细胞的活化这一过程。
"It has long been suspected that lipid metabolism is involved in the pathogenesis of acute pancreatitis," Dr. Daniel Closa from Institut d'Investigacions Biomediques, Barcelona, told Reuters Health. "Our work indicates a mechanism of action for several lipids in the exacerbation of the systemic inflammatory response associated with this disease."
“人们很早就知道脂类代谢在急性胰腺炎的发病中起着作用”，来自巴塞罗那的Institut d'Investigacions Biomediques 的Dr.DC告诉杂志的记者，“我们的工作就是确定在这个疾病中，脂质加重全身炎症反应的机制。”
Dr. Closa and colleagues examined the effect of the lipid fraction of pancreatitis-associated ascitic fluid generated in the early stages of acute pancreatitis. The findings are published in the May issue of Gut.
Dr.C和他的同事检查了在急性胰腺炎的早期，由胰腺炎造成的腹水中的脂质片段的作用。这项发现发表在了May issue of Gut。
High levels of thiobarbiturate acid reacting substances in the pancreatitis-associated ascitic fluid lipid extract indicated an intense oxidative alteration in the lipids contained in ascitic fluid, the investigators say.
研究者说，在由胰腺炎引起的腹水的患者的腹水中的脂质提取的结果中的高水平的硫巴比妥酸反应物证明了在腹水中大量的氧化改变的脂质。
These lipids obtained from pancreatitis-associated ascitic fluid reduced cell viability of macrophages and hepatocytes by 70%, the authors report, whereas lipids from white adipose tissue had no effect on cell viability.
据作者报道，这些从胰腺炎引起的腹水中获得的脂质减少了巨噬细胞和肝细胞的生存能力的70%，然而白色脂肪组织中的脂质却对细胞的生存能力没有影响。
Injection of complete pancreatitis-associated ascitic fluid or purified lipids obtained from pancreatitis-associated ascitic fluid into the portal vein increased serum AST, reflecting hepatotoxicity, but had no effect on serum lipase, indicating a lack of deleterious action in the pancreas, the researchers note.
注射完全胰腺炎源性的腹水或者纯化的此种腹水中的脂质到门静脉中可以是血浆中的天东门氨酸转移酶，反应了此物质的肝毒性，但是对于血浆中的脂肪酶却没有影响，这就说明了胰腺中并没有此有害的过程。
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作者:admin@医学,生命科学 2010-10-22 13:09
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