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【文摘发布】CT筛查到的I 期肺癌病人的生存情况
The International Early Lung Cancer Action Program Investigators
NEJM Volume 355:1763-1771 October 26, 2006 Number 17
ABSTRACT
Background The outcome among patients with clinical stage I cancer that is detected on annual screening using spiral computed tomography (CT) is unknown.
Methods In a large collaborative study, we screened 31,567 asymptomatic persons at risk for lung cancer using low-dose CT from 1993 through 2005, and from 1994 through 2005, 27,456 repeated screenings were performed 7 to 18 months after the previous screening. We estimated the 10-year lung-cancer–specific survival rate among participants with clinical stage I lung cancer that was detected on CT screening and diagnosed by biopsy, regardless of the type of treatment received, and among those who underwent surgical resection of clinical stage I cancer within 1 month. A pathology panel reviewed the surgical specimens obtained from participants who underwent resection.
Results Screening resulted in a diagnosis of lung cancer in 484 participants. Of these participants, 412 (85%) had clinical stage I lung cancer, and the estimated 10-year survival rate was 88% in this subgroup (95% confidence interval [CI], 84 to 91). Among the 302 participants with clinical stage I cancer who underwent surgical resection within 1 month after diagnosis, the survival rate was 92% (95% CI, 88 to 95). The 8 participants with clinical stage I cancer who did not receive treatment died within 5 years after diagnosis.
Conclusions Annual spiral CT screening can detect lung cancer that is curable.
http://content.nejm.org/cgi/content/full/355/17/1763 这篇文章我认领了哈，若48hs内没上传，请其他战友接力哈 Survival of Patients with Stage I Lung Cancer Detected on CT Screening
The International Early Lung Cancer Action Program Investigators
NEJM Volume 355:1763-1771 October 26, 2006 Number 17
题目：CT筛查到的I 期肺癌病人的生存情况
作者：国际早期肺癌行动组组员们
ABSTRACT
摘要
Background The outcome among patients with clinical stage I cancer that is detected on annual screening using spiral computed tomography (CT) is unknown.
研究背景：对每年一次CT检查而筛查出的临床Ⅰ期癌症患者的研究结果尚未知。
Methods In a large collaborative study, we screened 31,567 asymptomatic persons at risk for lung cancer using low-dose CT from 1993 through 2005, and from 1994 through 2005, 27,456 repeated screenings were performed 7 to 18 months after the previous screening.
方法：1993年至2005年间，在一次大样本合作研究中，我们用CT筛查了31,567位无症状的肺癌高危患者，且在1994至2005年间，27,456位可疑病例在前次筛查后的7－18个月内，再次接受了CT筛查。
We estimated the 10-year lung-cancer–specific survival rate among participants with clinical stage I lung cancer that was detected on CT screening and diagnosed by biopsy, regardless of the type of treatment received, and among those who underwent surgical resection of clinical stage I cancer within 1 month. A pathology panel reviewed the surgical specimens obtained from participants who underwent resection.
我们分别评估了其中经CT检测出并经活检证实的肺癌临床Ⅰ期患者【不管他们接受何种治疗方式】及在确诊一个月内便接受了肺癌切除术治疗的临床Ⅰ期患者的10年生存率。
Results Screening resulted in a diagnosis of lung cancer in 484 participants. Of these participants, 412 (85%) had clinical stage I lung cancer, and the estimated 10-year survival rate was 88% in this subgroup (95% confidence interval [CI], 84 to 91).
Among the 302 participants with clinical stage I cancer who underwent surgical resection within 1 month after diagnosis, the survival rate was 92% (95% CI, 88 to 95). The 8 participants with clinical stage I cancer who did not receive treatment died within 5 years after diagnosis.
结果：484位病例通过CT筛查确诊为肺癌，其中412例（85%）为临床Ⅰ期，预计十年生存率为88%（95% 可信区间 [CI],84%－ 91%），302位临床Ⅰ期患者在确诊一个月内便接受了肺癌切除术治疗，他们的十年生存率达92%（95% 可信区间 [CI],88%－ 95%）。而8例未接受治疗的肺癌临床Ⅰ期患者均在确诊后5年内死亡。
Conclusions Annual spiral CT screening can detect lung cancer that is curable.
结论：每年一次CT筛查有助于发现可治愈的早期肺癌
http://content.nejm.org/cgi/content/full/355/17/1763 再附上全文一篇：
h Stage I Lung Cancer Detected on CT Screening.doc (64.0k) 2005, 27,456 repeated screenings
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作者:admin@医学,生命科学 2011-01-12 05:14
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