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【medical-news】动物实验中治疗粉刺的药物与抑郁
动物实验中治疗粉刺的药物与抑郁症相关。
Reuters Health
Wednesday, September 27, 2006
By Amy Norton
NEW YORK (Reuters Health) - The active ingredient in the acne drug Accutane seems to cause depression-related behavior in mice, a study has found.
纽约（路透社健康消息）-一项研究表明粉刺治疗药物Accutane中的活性成分似乎能够引起小鼠的抑郁症相关行为。
Accutane, also sold generically as isotretinoin, has been linked to reports of depression and suicidal behavior among users. However, human studies have yielded conflicting results as to whether the drug itself contributes to these problems.
出售的Accutane,也叫做异维甲酸，与报道的使用者抑郁和自杀行为有关。然而，关于是否药物本身导致了这些问题而进行的人体研究却产生了矛盾的结果。
Depression is a complex disorder and, therefore, difficult to pin down to a single cause. For example, Accutane users often have severe acne, which itself may lead to depression.
抑郁症是一种复杂的病症，因此很难把它的发生归结于单一的因素。比如异维甲酸使用者常常患有严重的痤疮，这种病本身就可能导致抑郁症。
Because the new study was conducted in mice, researchers were able to examine the direct effects of Accutane's active ingredient on signs of depression -- which, in mice, manifests as listless, sedentary behavior.
因为这项新的研究在小鼠上进行，所以研究者能够检测异维甲酸的活性成分对抑郁症状的直接作用。抑郁的症状在小鼠身上表现为倦怠和久坐行为。
They found that mice given the drug every day for six weeks began to show such lethargy during tests that gauged their stress responses. In contrast, the animals showed no movement problems in other situations, including tests of physical coordination.
他们发现每天给予这种药物，持续六个周时，小鼠便开始在进行应激反应评估测试的时候表现出嗜睡。相比之下，这些动物在其他时候没有出现运动问题，包括机体协调性测试。
This suggests the drug's effects were depression-related, according to the researchers, led by Dr. Kally C. O'Reilly of the University of Texas at Austin.
奥斯汀的德州大学的Kally C. O'Reilly博士领导的研究者们认为这表明药物的作用与抑郁症有关。
They report the findings in the journal Neuropsychopharmacology.
他们在神经精神药理学杂志上发表了他们的发现。
For now, it's unclear whether the results might also apply to humans, study co-author Dr. Michelle A. Lane, also of UT Austin, told Reuters Health.
目前，还不清楚在人类是否会有同样的结果，论文的共同作者同属奥斯汀德州大学的Michelle A. Lane博士告诉路透社健康消息的记者。
These findings are "just the beginning," she explained, and more work needs to be done before a conclusive link can be made between Accutane use and depression.
这些发现仅仅是开始，她解释说，在得出Accutane的使用与抑郁症相关的明确结论之前，还有大量的工作要做。
The acne drug belongs to a family of compounds called retinoids, derivatives of vitamin A. It's known that retinoids can damage the developing fetal nervous system, which is why Accutane cannot be given to pregnant women.
这种痤疮治疗药物属于类视黄醇族化合物，是维生素A的衍生物。众所周知类视黄醇嫩能够损伤正在发育的胎儿的神经系统，因此孕妇不能使用。
In addition, there is growing interest in how retinoids might affect the adult brain, according to O'Reilly's team.
另外，据O'Reilly研究小组说，类视黄醇如何影响成人大脑也越来越引起关注。
Based on evidence from previous research, they note, Accutane might alter the regulation of brain chemicals like dopamine and serotonin, which are implicated in depression. Another possibility is that the drug might affect the production or survival of cells in brain regions linked to depression.
基于以前研究所得到的证据，他们提到，Accutane可能改变人脑中对化学物质如多巴胺和5-羟色胺的调节，这可能与抑郁症有关。另一种可能性是这种药物可能影响抑郁症相关脑区的产物或者细胞的存活。
This is, however, still speculation. Little is known about how Accutane may work in the human brain. One brain-scan study of acne patients found that those treated with Accutane showed lesser activity in an area of the brain related to depression, but they weren't more likely than other patients to suffer depression.
然而，这仍然是推测。对Accutane在脑中如何作用还知之甚少。一项对痤疮患者脑扫描的研究发现那些经过Accutan治疗的患者的抑郁症相关脑区活动减少，但是他们并不比别的患者更易于患上抑郁症。
Between 1982 and 2000, the U.S. Food and Drug Administration received 431 reports of depression, suicide or suicidal behavior among Accutane users.
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作者:admin@医学,生命科学 2011-08-23 05:12
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