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【medical-news】研究发现：他汀类药物可能有助于
WASHINGTON (Reuters) - Cholesterol-fighting statin drugs, already known to help ward off heart attack and stroke, may help people who have received a kidney transplant live longer, researchers said on Wednesday.
The study, published in the Journal of the American Society of Nephrology, is the latest to show that this widely used class of drugs may provide additional health benefits beyond lowering blood cholesterol levels.
Researchers led by Dr. Rainer Oberbauer of the Medical University of Vienna in Austria tracked 2,041 patients who underwent kidney transplants between 1990 and 2003. At the time of the operation, 302 were taking statin drugs to lower blood cholesterol levels and 1,739 were not.
After being followed for 12 years, 73 percent of the people taking statins were alive, compared to 64 percent of those who were not taking statins, the researchers said.
About 60 percent of patients with kidney transplants die of cardiovascular disease, the researchers noted, and statins have been shown to be effective against cardiovascular disease.
After statistically accounting for factors such as the fact that people on statins have more cardiovascular risk factors and disease, the researchers found that the kidney transplant patients who were taking statins had a 36 percent lower risk of death during the study than those not using the drugs.
"This study provides evidence that statin treatment is associated with reduced all-cause mortality in renal transplant recipients," the researchers wrote.
They said further research is needed to confirm that statins are causing the improvements.
Statins work by lowering the production of cholesterol by the liver, and are most effective at reducing low-density lipoprotein, or LDL, the so-called bad cholesterol.
A number of studies have indicated statins may offer other benefits including reducing the risk of getting cancer and lowering the risk of death from influenza, pneumonia and smoking.
Some statins include Pfizer Inc's Lipitor, Merck & Co's Zocor, AstraZeneca's Crestor and Bristol-Myers Squibb Co's Pravachol.
The study was backed by grants from the Austrian Science Fund and the Austrian Academy of Science.
http://www.reuters.com/article/healthNews/idUSN2342075820080723?pageNumber=2&virtualBrandChannel=10222 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 研究发现：他汀类药物可能有助于肾移植病人
Statins may help kidney transplant patients: study
WASHINGTON (Reuters) - Cholesterol-fighting statin drugs, already known to help ward off heart attack and stroke, may help people who have received a kidney transplant live longer, researchers said on Wednesday.
华盛顿（路透社）---周三有研究者报道，降胆固醇的他汀类药物，已经知道有助于避免心脏病发作和中风，可能还可使接受肾脏移植的患者存活更长时间。
The study, published in the Journal of the American Society of Nephrology, is the latest to show that this widely used class of drugs may provide additional health benefits beyond lowering blood cholesterol levels.
发表在美国肾病学会杂志的最新研究表明，这种广泛使用的药物能在降低血中胆固醇的之外，还能提供更多的健康作用。
Researchers led by Dr. Rainer Oberbauer of the Medical University of Vienna in Austria tracked 2,041 patients who underwent kidney transplants between 1990 and 2003. At the time of the operation, 302 were taking statin drugs to lower blood cholesterol levels and 1,739 were not.
来自澳地利维也纳医科大学的Rainer博士领导了这项研究。研究者跟踪了2041名在1990年到2003年间接受肾脏移植的患者。在手术期间，302名患者服用他汀类药物降低血中胆固醇而1739名患者没有服用。
After being followed for 12 years, 73 percent of the people taking statins were alive, compared to 64 percent of those who were not taking statins, the researchers said.
研究者说，在跟踪调查12年后，未服用他汀类药物的患者有64%存活，与此相比，服用他汀类药物的患者有73%还存活。
About 60 percent of patients with kidney transplants die of cardiovascular disease, the researchers noted, and statins have been shown to be effective against cardiovascular disease.
研究者注意到约60%的接受肾脏移植的患者死于心血管疾病，而他汀类药物能有效的治疗心血管疾病。
After statistically accounting for factors such as the fact that people on statins have more cardiovascular risk factors and disease, the researchers found that the kidney transplant patients who were taking statins had a 36 percent lower risk of death during the study than those not using the drugs.
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作者:admin@医学,生命科学 2011-08-12 17:22
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