主页 > 医学讨论 >
【medical-news】对抑郁症的深部脑刺激
July 23, 2008 -- A new small study shows that deep brain stimulation can improve life for those with treatment-resistant depression.
Patients with treatment-resistant depression continue to have severe depression despite being treated with maximum medical therapy.
Deep brain stimulation is done by implanting electrodes in the brain that send electrical impulses to specific parts of the brain.
For those with major depression, the electrodes are placed in the part of the brain that regulates mood.
That part of the brain is shown to be overactive in depressed people, and while researchers are not certain how deep brain stimulation works, it's believed that stimulating the area can help treat depression.
Researchers implanted electrodes in the brains of 20 people who were in a major depressive episode.
Nine of them were men, 11 women; all of them were in their 40s.
The study was in two parts. Six patients were treated with deep brain stimulation in 2005; the new results followed up another 14 people for a year.
Researchers found that after getting deep brain stimulation, patients were calmer, had improved moods, and were more interested and motivated in life.
The effects lasted up to a year in the 14 people who were followed up for that long.
"Our research confirmed that 60% of patients have shown a clinically significant response to the surgery and the benefits were sustained for at least one year," says researcher Andres Lozano, MD, in a news release. Lozano is a neurosurgeon at Krembil Neurosciences Centre-Toronto Western Hospital.
"The underpinnings of depression are poorly understood and this therapy, although not perfect, offers numerous advantages."
Some of those advantages, he adds, beyond lifting depression, are that the procedure carries little risk and has few side effects.
One patient who received the procedure said it "gave him his life back." In a news release, study participant Sean Miller says, "The pain, fear, anxiety and depression are pretty much completely gone and I am now a very happy, healthy, working, active, fulfilled and grateful individual."
Researchers are calling for wider study before recommending that people with major depression get deep brain stimulation.
In background information published with the study results, the researchers write that 10% to 20% of depressed people do not respond to typical treatment like psychotherapy, antidepressants, or electroconvulsive therapy.
This type of treatment-resistant depression is one of the major causes of suicide, according to the researchers.
The results are published online in Biological Psychiatry.
http://www.webmd.com/depression/news/20080723/deep-brain-stimulation-helps-depression Deep Brain Stimulation for Depression
对抑郁症的深部脑刺激疗法
July 23, 2008 -- A new small study shows that deep brain stimulation can improve life for those with treatment-resistant depression.
2008.7.23 -------一项新的研究显示深部脑刺激能改善难治性抑郁症患者生活
Patients with treatment-resistant depression continue to have severe depression despite being treated with maximum medical therapy.
对难治性抑郁症患者即使使用最大剂量的药物治疗仍然会表现严重的抑郁。
Deep brain stimulation is done by implanting electrodes in the brain that send electrical impulses to specific parts of the brain.
脑深部电刺激是通过在脑内特定区域植入能够发出电脉冲的电极来实现的。
For those with major depression, the electrodes are placed in the part of the brain that regulates mood.
对于严重的抑郁症，是把电极放到大脑调节情绪的区域。
That part of the brain is shown to be overactive in depressed people, and while researchers are not certain how deep brain stimulation works, it's believed that stimulating the area can help treat depression.
抑郁症患者大脑的这个特定区域表现为过度兴奋，虽然研究者并不完全确定脑深部电刺激的工作原理，但相信刺激这个特定区域能够帮助治疗抑郁症。
Researchers implanted electrodes in the brains of 20 people who were in a major depressive episode.
研究人员向20名抑郁症患者的大脑中植入了电极。
Nine of them were men, 11 women; all of them were in their 40s.
其中有9名男性，11名女性，年龄分布在40-50之间。
The study was in two parts. Six patients were treated with deep brain stimulation in 2005; the new results followed up another 14 people for a year.
这项研究分为两个部分。6名患者在2005年实施了脑刺激；对实施新方法的另外14名患者随访了一年。
Researchers found that after getting deep brain stimulation, patients were calmer, had improved moods, and were more interested and motivated in life.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-07-30 17:33
医学,生命科学网