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【medical-news】髋骨可能为乳腺癌提供线索
July 28, 2008 -- Hip bone mineral density may be a clue in predicting breast cancer after menopause, a new study shows.
The study, which appears in the Sept. 1 edition of Cancer, links higher hip bone density to increased breast cancer risk in postmenopausal women.
Higher hip bone mineral density may be a reflection of greater lifetime exposure to estrogen; many (but not all) breast cancers are estrogen-sensitive.
Of course, if bone mineral density drops too low, that brings different health risks -- osteoporosis and fractures.
Cancer is published by the American Cancer Society. An American Cancer Society news release states that the study's findings don't change "the need to treat osteoporosis in order to reduce the risk of fractures."
Bone Mineral Density and Breast Cancer Risk
The new study is based on 9,941 postmenopausal women who took part in the Women's Health Initiative, a long-term women's health study.
When the study started, the women were 63 years old, on average. They got a checkup that included a hip bone mineral density scan using dual-energy X-ray absorptiometry (DXA). They also completed questionnaires about their medical history and lifestyle every six months.
The women were followed for about eight years; during that time, 327 women were diagnosed with breast cancer.
Women with high hip bone mineral density at the study's start were more likely to develop breast cancer during the study, report the researchers, who included Zhao Chen, PhD, MPH, of the University of Arizona College of Public Health in Tucson, Ariz.
BMI (body mass index) or hormone replacement therapy when the study started didn't explain the results. Race didn't, either, but because most of the women were white, that needs to be checked in other studies.
Hip bone mineral density also helped predict breast cancer risk beyond the Gail risk model, which is for women who are at least 35 years old. The Gail risk model estimates a woman's odds of developing breast cancer based on her current age, her age when she first menstruated, her age when she first gave birth, family history of breast cancer, past biopsies, and race.
In Chen's study, the hip bone mineral density score and the Gail score were "similar" in predicting breast cancer. Using both of those scores together may further help predict breast cancer in postmenopausal women, the researchers note. Women with high hip bone density and high Gail scores were particularly likely to develop breast cancer during the study.
Chen's study, which was funded by the drug company Lily, doesn't make new recommendations about getting DXA bone density tests. The study doesn't change the use of bone mineral density testing to diagnose osteoporosis, states the American Cancer Society news release.
A 2005 study published in the Journal of the National Cancer Institute showed no relationship between bone mineral density and breast cancer risk. That study, conducted in San Francisco, mainly included postmenopausal women, but premenopausal women were also included.
http://www.webmd.com/breast-cancer/news/20080728/hip-bone-may-hold-breast-cancer-clue 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Hip Bone May Hold Breast Cancer Clue
髋骨可能为乳腺癌提供线索
July 28, 2008 -- Hip bone mineral density may be a clue in predicting breast cancer after menopause, a new study shows.
2008年7月28日 最新的研究表明：髋骨的无机盐密度可以预测绝经后乳腺癌的发生。
The study, which appears in the Sept. 1 edition of Cancer, links higher hip bone density to increased breast cancer risk in postmenopausal women.
这项研究发表在9月份的《肿瘤》第一期上，研究指出：绝经后的妇女如果有较高的髋骨密度可能会增加患乳腺癌的风险。
Higher hip bone mineral density may be a reflection of greater lifetime exposure to estrogen; many (but not all) breast cancers are estrogen-sensitive.
较高的髋骨骨密度可以间接的反映暴露于雌激素作用下的时间更长，而很多（不是全部）乳腺癌恰恰是属于雌激素敏感型的。
Of course, if bone mineral density drops too low, that brings different health risks -- osteoporosis and fractures.
当然，如果骨密度过低，也会导致不同的疾病---如骨质疏松与骨折。
Cancer is published by the American Cancer Society. An American Cancer Society news release states that the study's findings don't change "the need to treat osteoporosis in order to reduce the risk of fractures."
《肿瘤》 是由美国肿瘤协会出版的。美国肿瘤协会对此发表了一项新的申明：研究的结果不会改变“为减少骨折风险而采取的针对骨质疏松症的治疗”。
Bone Mineral Density and Breast Cancer Risk
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作者:admin@医学,生命科学 2011-07-30 05:14
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