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【medical-news】曲霉菌是急性髓细胞白血病患儿感
By Scott Baltic
NEW YORK (Reuters Health) Dec 14 - Aspergillus species are the largest contributor to infectious deaths among children with acute myeloid leukemia (AML), according to U.S. and Canadian researchers. They also found that age, ethnicity and body mass index (BMI) were significant predictors of infection-related mortality in these children.
In a study published in the November 15th issue of Blood, lead investigator Dr. Lillian Sung and associates describe the infection characteristics, prevalence, and infection-related mortality in 492 children with AML. They also looked for predictors of infection-related mortality.
The subjects (21 years old or younger, median 9.6 years) were members of the Children's Cancer Group trial 2961, enrolled between August 1996 and October 1999.
During three phases of chemotherapy, 60% had at least one microbiologically documented infection. Gram-positive cocci were the most common cause of infections, specifically coagulase-negative Staphylococcus and alpha hemolytic Streptococcus.
These two bacteria, along with Candida species and Aspergillus species, were among the most common etiologic agents related to infectious deaths, with Aspergillus responsible for the most. Overall, infections killed about 11% of the children in this study.
"Ensuring careful investigation and treatment of fungal infections in febrile children and continuing broad-spectrum antibiotic therapy, even when a source of infection is identified, are important goals of therapy," Dr. Sung of the Hospital for Sick Children, Toronto, told Reuters Health.
The researchers emphasized that polymicrobial infection-related mortality was more common than single-pathogen infection-related mortality.
Both underweight and overweight children had higher-than-average mortality (3-fold increase and 1.5-fold increase, respectively). In addition, non-white children were more likely to die of infection, as were children older than 16 compared with those between 2 and 16 years old.
Dr. Sung mentioned several possible explanations for the BMI results. First, children who are underweight or overweight might have other underlying conditions or illnesses that make them more predisposed to dying of infection.
In addition, malnutrition may make some of these children less resilient to infection, or some of them may have a "different intensity of chemotherapy exposure, which may make them more immunosuppressed."
Blood 2007;110:3532-3539.
http://www.medscape.com/viewarticle/567535 Aspergillus Most Deadly Infection in Children With AML
曲霉菌是儿童急性髓细胞样白血病感染致死的主要原因急性髓细胞白血
By Scott Baltic
NEW YORK (Reuters Health) Dec 14 - Aspergillus species are the largest contributor to infectious deaths among children with acute myeloid leukemia (AML), according to U.S. and Canadian researchers. They also found that age, ethnicity and body mass index (BMI) were significant predictors of infection-related mortality in these children.
纽约（路透社－健康部）2007年12月14日 根据美国及加拿大的研究者们的研究结果，曲霉菌感染是儿童急性髓细胞样白血病感染致死的主要死因。他们同时发现，年龄，种族，和体重指数是这些儿童感染相关性死亡的重要预测因子。
In a study published in the November 15th issue of Blood, lead investigator Dr. Lillian Sung and associates describe the infection characteristics, prevalence, and infection-related mortality in 492 children with AML. They also looked for predictors of infection-related mortality.
发表在11月的第15期的《血液》杂志上的研究结果阐述了在492名儿童急性髓细胞样白血病患者中感染的特征，流行病学特点，以及感染相关的死亡率。这个研究由Lillian Sung医生和他的同事们完成。他们同时寻找了感染相关性死亡的预测因子。
The subjects (21 years old or younger, median 9.6 years) were members of the Children's Cancer Group trial 2961, enrolled between August 1996 and October 1999.
研究的患者（是21岁以下，平均年龄9.6岁）是儿童肿瘤人群试验2961中的成员，在1996年的8月到1999年的10月之间入组。
During three phases of chemotherapy, 60% had at least one microbiologically documented infection. Gram-positive cocci were the most common cause of infections, specifically coagulase-negative Staphylococcus and alpha hemolytic Streptococcus.
在三个化疗期时间内，60％的患者至少患有一种以上存有微生物学病原学证据的感染。革兰(氏)阳性球菌是最常见的感染的引起原因，尤其是凝固酶阴性葡萄球菌和甲型溶血性链球菌。
These two bacteria, along with Candida species and Aspergillus species, were among the most common etiologic agents related to infectious deaths, with Aspergillus responsible for the most. Overall, infections killed about 11% of the children in this study.
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作者:admin@医学,生命科学 2011-08-06 05:14
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