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【medical-news】干细胞修补“破碎的心”：有助于
LONDON (Reuters) - Scientists have made two significant advances in developing a stem-cell patch to repair the damage caused to the heart after an attack.
Sian Harding of London's Imperial College said on Thursday her team had successfully matured beating heart cells in a laboratory dish for up to seven months and developed a biocompatible scaffold to form the basis of a patch.
The idea is to stitch or glue a patch of new tissue derived from embryonic stem cells over the damaged area of the heart to make the muscle viable again.
During a heart attack, or myocardial infarct, part of the heart muscle loses its blood supply and the oxygen-starved cells die, causing scarring.
"We really would like to cover the area of the infarct scar as much as possible, so it might be quite a large patch," Harding said in an interview.
"We think the patch itself will stop the scar expanding, which is one of the big problems when you have a myocardial infarction because the scar becomes weak and can bulge out."
The biomaterial developed for the patch is designed to have the same elasticity as heart muscle and can also be programmed to degrade safely in anything from two weeks upwards.
Several groups around the world are working on different ways to use stem cells in heart repair but a key challenge is to get cells to function properly.
By showing stem cell-derived heart cells can beat in a co-ordinated fashion for months on end, the Imperial team believes their patch should function smoothly alongside normal heart muscle, without causing abnormal heart rhythms.
Harding, who will present her research at a UK Stem Cell Initiative conference, said initial human trials of the patch could be underway within five years -- after safety studies on animals and tests to see if the new cells are rejected.
Stem cells are controversial but the field received a boost last month when researchers reported they had turned ordinary human skin cells into batches of cells that looked and acted like embryonic stem cells, without using human eggs or embryos.
"That is a very promising development," Harding said. "They have made heart muscles from those cells and this technique has the potential both for getting round the ethical problems and for producing patient-specific cells."
Making stem cells from a patient's own tissue would avoid the problems of transplant rejection.
http://www.reuters.com/article/healthNews/idUSL1215719320071213 干细胞修补“破碎的心”：有助于心梗的恢复 楼上的战友是用google翻译的吧？ Stem-cell patch may fix damaged hearts
干细胞片可能固定被损坏的心
看了标题的翻译，我就在想：是楼主翻译的水平问题？还是翻译的态度问题？ fix：基本意思在此处取“修补、修好”之意吧，更专业一点要思考一下，但“固定”万万不可取！
此篇文章机器翻译的痕迹很重！ Stem-cell patch may fix damaged hearts
干细胞补片可能修复损伤的心脏
LONDON (Reuters) - Scientists have made two significant advances in developing a stem-cell patch to repair the damage caused to the heart after an attack.
伦敦 (路透社)----科学家们已经在应用干细胞补片修复心脏病所致心脏损伤方面取得了两项重要进展。
Sian Harding of London's Imperial College said on Thursday her team had successfully matured beating heart cells in a laboratory dish for up to seven months and developed a biocompatible scaffold to form the basis of a patch.
周四，伦敦帝国学院的Sian Harding宣称她的团队已经在实验室成功地培育出跳动长达7个月的心肌细胞，并研制出形成补片基础形状的生物相容性支架。
The idea is to stitch or glue a patch of new tissue derived from embryonic stem cells over the damaged area of the heart to make the muscle viable again.
方法是将一个来源于胚胎干细胞的新组织补片“缝到”或“粘到”心脏的损伤区域，让心肌再次成活。
During a heart attack, or myocardial infarct, part of the heart muscle loses its blood supply and the oxygen-starved cells die, causing scarring.
当心脏病发作或心肌梗死时，部分心肌丧失了血供，同时缺氧的细胞坏死，导致瘢痕形成。
"We really would like to cover the area of the infarct scar as much as possible, so it might be quite a large patch," Harding said in an interview.
Harding在一次采访中说：“我们确实想尽量覆盖心梗后的瘢痕区域，所以可能要很大的补片。”
"We think the patch itself will stop the scar expanding, which is one of the big problems when you have a myocardial infarction because the scar becomes weak and can bulge out."
“我们认为补片本身能够阻止瘢痕的增大，当你患心梗时瘢痕增大是一个大问题，因为瘢痕会变得脆弱并膨出。”
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作者:admin@医学,生命科学 2011-08-05 17:16
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