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【bio-news】科学家发现乳腺癌新途径
Breast cancer: Researchers discover new path
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A team directed by Michel L. Tremblay at the Cancer Centre at McGill University has uncovered the role played by a gene associated with the propagation of breast cancer in two of five affected women.
Their study, published in the magazine Nature Genetics, shows that halting the activity of this gene in mice predisposed to cancer slowed the growth of — and in some cases, prevented — tumors.
"The gene we identified, PTP1b, is known for its role in diabetes and obesity," explained Dr. Michel L. Tremblay, Director of the McGill Centre for Cancer Research. "In this new study, we found that the role of PTP1b in modulating metabolism is equally crucial in the promotion of the proliferation and metastasis of cancer tumors."
An article published by the same group of researchers in Science in 1999 showed that suppressing the enzyme produced by the gene PTP1b made it possible to cure type II diabetes and obesity. A large number of pharmaceutical companies have since developed new inhibitors used in treatments for these diseases.
"Adapting these compounds is all that is needed to attack breast cancer," continued Dr. Tremblay.
"Although this study is simply a genetic and pharmacologic validation in mice, we know that 30% to 40% of all cases of breast cancer involve different levels of over-expression of PTP1b — which is a much greater proportion than is found in cases linked to hereditary baggage," concluded Dr. Tremblay.
On the Net: http://www.nature.com/ng/journal/vaop/ncurrent/full/ng1963.html 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Breast cancer: Researchers discover new path
研究者发现治疗乳腺癌新途径
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A team directed by Michel L. Tremblay at the Cancer Centre at McGill University has uncovered the role played by a gene associated with the propagation of breast cancer in two of five affected women.
由在McGill大学癌症中心Michel L. Tremblay领导的团队，在五名感染乳腺癌的妇女的两名妇女中已经发现一个基因在乳腺癌传播中扮演的角色。
Their study, published in the magazine Nature Genetics, shows that halting the activity of this gene in mice predisposed to cancer slowed the growth of — and in some cases, prevented — tumors.
他们的刊登在《自然遗传杂志上》研究，显示了在小鼠中这个基因活性的不完善可以使癌症增长减缓并且在某些情况下阻止肿瘤的发生。
"The gene we identified, PTP1b, is known for its role in diabetes and obesity," explained Dr. Michel L. Tremblay, Director of the McGill Centre for Cancer Research. "In this new study, we found that the role of PTP1b in modulating metabolism is equally crucial in the promotion of the proliferation and metastasis of cancer tumors."
McGill癌症研究中心主任Michel L. Tremblay医生说，“我们鉴定的这个基因是PTP1b，我们已经知道它在糖尿病和肥胖症扮演的角色。”“在这项新的研究中，我们发现PTP1b在调节代谢重的角色是相当关键的，它可以促进癌症肿瘤的增殖和转移.”
An article published by the same group of researchers in Science in 1999 showed that suppressing the enzyme produced by the gene PTP1b made it possible to cure type II diabetes and obesity. A large number of pharmaceutical companies have since developed new inhibitors used in treatments for these diseases.
同样来自这个组织重的研究者在1999年《科学》杂志发表的另一篇文章显示了抑制PTP1b基因产生的酶活性可以治疗二期糖尿病和肥胖疾病。很多大型制药公司因此开发了对于这些疾病的新抑制剂。
"Adapting these compounds is all that is needed to attack breast cancer," continued Dr. Tremblay.
Tremblay医生继续说道，“需要改变这些化合物来同乳腺癌进行斗争.”
"Although this study is simply a genetic and pharmacologic validation in mice, we know that 30% to 40% of all cases of breast cancer involve different levels of over-expression of PTP1b — which is a much greater proportion than is found in cases linked to hereditary baggage," concluded Dr. Tremblay.
Tremblay总结到，“尽管这项研究是在小鼠中使用简单的基因和药理学确证，我们知道所有乳腺癌例子中的30％～40％都包含PTP1b基因的过度表达--这在某些情况下要超过遗传学观点所占的比例。”
研究者发现治疗乳腺癌新途径
由在McGill大学癌症中心Michel L. Tremblay领导的团队，在五名感染乳腺癌的妇女的两名妇女中已经发现一个基因在乳腺癌传播中扮演的角色。
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作者:admin@医学,生命科学 2011-03-10 17:14
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