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【Cancer cell】HECT家族E3泛素连接酶在肿瘤发生中的
The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WWK-4SXRJ04-5&_user=44062&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000004738&_version=1&_urlVersion=0&_userid=44062&md5=45283fcc17a198a3caafbf0162baaaf7 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-07-29 05:18
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