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【文摘发布】预测鼻咽癌适形放疗后远处转移的
AUTHOR: Skye Hongiun Cheng, James J Jian, Stella Y Tsai, Cheng-Fang Horng, Kwan-Yee Chan, Jin-Chin Lin, Ching-Yuan Lin, Shyuang-Der Terng,
Mei-Hua Tsou, Nei-Min Chu, K Lawrence Yen, Hsin-Hsian Chen, K H Chi, T W Liu, Andrew T Huang
LINK:http://multimedia.thelancet.com/pdf/ASIAFORUM2007_CHENG_P002.pdf
Background The purpose of this study was to establish a prognostic score for nasopharyngeal carcinoma (NPC) that could estimate the probability of distant metastasis after conformal radiotherapy.
Methods 735 patients who had NPC but no distant metastasis at initial presentation between 1990 and 2003 were enrolled in this study for training for model and for validation. A further 144 patients were used as a test group. Variables, including extent of primary tumour affecting the surrounding anatomic structures, age at diagnosis, primary-tumour size, tumour and nodal classification, histology type, and lactose dehydrogenase (LDH) serum concentration before treatment were used in the analysis to build a prognostic scoring system. The endpoint was distant metastasis.
Findings The prognostic scoring system comprised: increasing neck lymph-node size (cm), increasing LDH serum concentration (per 100U/L), age >45 years, anatomic grouping 3 (sphenoid sinus, foramen lacerum, foramen ovale, Meckel’s cave, cavernous sinus, and intracranium) involvement, and nodal stage IIIB disease. The score predicted the 5-year probability of distant-metastasis-free survival as follows: score <15 (27% of patients), 97%; 15·1–75 (44%), 86%; and >75 (29%), 64%. This new prognostic score was validated and tested independently in two different samples (p=0·001 and p=0·027, respectively) and could separate patients into three distinct risk groups.
Interpretation This new prognostic score is useful in making individual therapeutic decisions and in designing clinical trials to reduce distant metastasis for advanced-stage NPC. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 TITLE: New prognostic score to predict distant metastasis in nasopharyngeal carcinoma after conformal radiotherapy
题目：一种用于预测鼻咽癌适形放疗后远程转移的新型预后评分系统
AUTHOR: Skye Hongiun Cheng, James J Jian, Stella Y Tsai, Cheng-Fang Horng, Kwan-Yee Chan, Jin-Chin Lin, Ching-Yuan Lin, Shyuang-Der Terng,Mei-Hua Tsou, Nei-Min Chu, K Lawrence Yen, Hsin-Hsian Chen, K H Chi, T W Liu, Andrew T Huang
作者：Skye Hongiun Cheng, James J Jian, Stella Y Tsai, Cheng-Fang Horng, Kwan-Yee Chan, Jin-Chin Lin, Ching-Yuan Lin, Shyuang-Der Terng,Mei-Hua Tsou, Nei-Min Chu, K Lawrence Yen, Hsin-Hsian Chen, K H Chi, T W Liu, Andrew T Huang
Background: The purpose of this study was to establish a prognostic score for nasopharyngeal carcinoma (NPC) that could estimate the probability of distant metastasis after conformal radiotherapy.
背景：此项研究的目的是建立一种鼻咽癌预后评分系统，来预测鼻咽癌适形放疗后远程转移的几率。
Methods: 735 patients who had NPC but no distant metastasis at initial presentation between 1990 and 2003 were enrolled in this study for training for model and for validation. A further 144 patients were used as a test group. Variables, including extent of primary tumour affecting the surrounding anatomic structures, age at diagnosis, primary-tumour size, tumour and nodal classification, histology type, and lactose dehydrogenase (LDH) serum concentration before treatment were used in the analysis to build a prognostic scoring system. The endpoint was distant metastasis.
方法：735名1990-2003年开始患鼻咽癌但未曾远程转移的患者参加此次研究作为模型组和验证组。另外144名患者作为测试组。用于分析并建立预后评分系统的变量包括原发性肿瘤对周围解剖结构的影响程度，就诊时的年龄，原发性肿瘤的大小，肿瘤和结节的分类，组织学类型和治疗前血清乳糖脱氢酶的浓度。评价终点是远程转移。
Findings: The prognostic scoring system comprised: increasing neck lymph-node size (cm), increasing LDH serum concentration (per 100U/L), age >45 years, anatomic grouping 3 (sphenoid sinus, foramen lacerum, foramen ovale, Meckel’s cave, cavernous sinus, and intracranium) involvement, and nodal stage IIIB disease. The score predicted the 5-year probability of distant-metastasis-free survival as follows: score <15 (27% of patients), 97%; 15•1–75 (44%), 86%; and >75 (29%), 64%. This new prognostic score was validated and tested independently in two different samples (p=0•001 and p=0•027, respectively) and could separate patients into three distinct risk groups.
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作者:admin@医学,生命科学 2011-06-29 18:20
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