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【科普】抗氧化剂可轻度增加死亡风险
Reuters Health
Tuesday, February 27, 2007
NEW YORK (Reuters Health) - People seeking to improve their health with vitamin supplements may want to think twice before popping pills containing vitamin A, vitamin E, and beta-carotene. New research suggests that these antioxidants may actually increase the risk of death by 5 percent.
In contrast, the Danish researchers did not discern any significant influence of vitamin C and selenium on longevity, according to the report in the Journal of the American Medical Association.
Antioxidant supplements are popular among consumers, based on studies claiming that antioxidants improve health and prevent disease, Dr. Goran Bjelakovic and his colleagues note. But other reviews and guidelines suggest that antioxidant supplements may be of no benefit.
Bjelakovic and associates searched the medical literature through 2005 to identify trials involving adult subjects comparing beta-carotene, vitamin A, vitamin C, vitamin E, and selenium, singly or combined, versus inactive "placebo" or versus no treatment.
Their search turned up 68 trials with 232,606 participants.
When all trials were considered, antioxidant supplements had no effect on the risk of death. However, when the analysis was limited to only the highest quality studies, the supplements increased the risk of death by 5 percent.
Further analysis showed that only vitamin A, vitamin E, and beta carotene seemed to increase the risk of death, not vitamin C or selenium. The untoward effect of these antioxidants was noted whether they were taken separately or together.
It is estimated that up to 20 percent of adults in North America and Europe consume antioxidant supplements, so "the public health consequences may be substantial," Bjelakovic's team maintains.
The authors stress, however, that they evaluated only synthetic antioxidants, so their "findings should not be translated to potential effects of fruits and vegetables."
SOURCE: Journal of the American Medical Association, February 28, 2007.
http://www.nlm.nih.gov/medlineplus/news/fullstory_45846.html 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Antioxidants may slightly raise risk of death
抗氧化剂可轻度增加死亡风险
Reuters Health
Tuesday, February 27, 2007
NEW YORK (Reuters Health) - People seeking to improve their health with vitamin supplements may want to think twice before popping pills containing vitamin A, vitamin E, and beta-carotene. New research suggests that these antioxidants may actually increase the risk of death by 5 percent.
纽约路透社报道――想通过补充维生素而提高健康的人，在取出包含维生素A、维生素E及β-胡萝卜素的片剂前应该三思而后行。新的研究表明，这些抗氧化剂实际上可使死亡风险增加5％。
In contrast, the Danish researchers did not discern any significant influence of vitamin C and selenium on longevity, according to the report in the Journal of the American Medical Association.
据《美国医学协会杂志》报道，丹麦研究者也发现维生素C和硒对长寿并没有显著作用。
Antioxidant supplements are popular among consumers, based on studies claiming that antioxidants improve health and prevent disease, Dr. Goran Bjelakovic and his colleagues note. But other reviews and guidelines suggest that antioxidant supplements may be of no benefit.
Goran Bjelakovic及同事说，由于有研究报道抗氧化剂能提高健康、预防疾病，所以补充抗氧化剂在广大消费者中普遍存在。但是，其它评论及指导方针称补充抗氧化剂并无益处。
Bjelakovic and associates searched the medical literature through 2005 to identify trials involving adult subjects comparing beta-carotene, vitamin A, vitamin C, vitamin E, and selenium, singly or combined, versus inactive "placebo" or versus no treatment.
Bjelakovic与同事对2005年的医学文献进行搜索，找出涉及比较β-胡萝卜素、维生素A、维生素C、维生素E及硒单独或联合应用的成人受试者的实验，与无活性安慰剂组或未处理组进行比较。
Their search turned up 68 trials with 232,606 participants.
他们共搜索出涉及232，606名受试者的68 例实验。
When all trials were considered, antioxidant supplements had no effect on the risk of death. However, when the analysis was limited to only the highest quality studies, the supplements increased the risk of death by 5 percent.
通过对所有实验进行分析发现，补充抗氧化剂对死亡风险无影响。然而，当分析范围限定到只有最高质量的研究时，补充抗氧化剂增加了5％的死亡风险。
Further analysis showed that only vitamin A, vitamin E, and beta carotene seemed to increase the risk of death, not vitamin C or selenium. The untoward effect of these antioxidants was noted whether they were taken separately or together.
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作者:admin@医学,生命科学 2011-06-27 17:44
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