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【medical-news】目前研究显示乳腺癌无明显遗传倾
Research reported today should provide relief to women who are worried after a relative's breast cancer diagnosis. The study shows that a family history of breast cancer does not give a useful indication of the likelihood that a woman will develop it herself at an early age.
An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies. As physicians and the general population have become more aware of this increased risk, the demand for referring healthy women with a family history of breast cancer for intensive screening or genetic testing has risen. Geertruida H. de Bock led a team from Leiden University Medical Centre in the Netherlands who investigated whether the increased risk was significant enough to accurately predict breast cancer.
According to de Bock, "Due to the low prevalence of early breast cancer in the population, the predictive value of a family history of breast cancer was 13% before the age of 70, 11% before the age of 50, and 1% before the age of 30." These numbers are much lower than most women would probably expect. As the authors explain, "Applying family history related criteria results in the screening of many women who will not develop breast cancer at an early age."
Given the psychological harm that screening visits can cause, more stringent criteria should be applied to early screening. The researchers recommend that these results be used to "reassure a large number of women regarding their personal breast cancer risk."
http://www.sciencedaily.com/releases/2008/07/080722192348.htm 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 No Need For Gene Screens In Breast Cancer Families, Study Shows
研究表明对于乳腺癌家系进行基因筛查是没有必要的
1. Research reported today should provide relief to women who are worried after a relative's breast cancer diagnosis. The study shows that a family history of breast cancer does not give a useful indication of the likelihood that a woman will develop it herself at an early age.
最新的研究可以让乳腺癌患者的女性亲属们松一口气，因为研究表明，乳腺癌的家族史并不意味着一个女性发生乳腺癌的风险增加或时间提前。
2. An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies. As physicians and the general population have become more aware of this increased risk, the demand for referring healthy women with a family history of breast cancer for intensive screening or genetic testing has risen. Geertruida H. de Bock led a team from Leiden University Medical Centre in the Netherlands who investigated whether the increased risk was significant enough to accurately predict breast cancer.
许多研究认为，乳腺癌患者的亲属罹患乳腺癌的风险较高。随着医生，以及健康大众对这一问题的关注，要求对于有乳腺癌家族史的女性进行遗传监测和筛查的呼声也越来越高。对此，荷兰莱顿大学医学中心的Geertruida H. de Bock 进行了一项研究，以确定这种风险的增加是不是可以准确预测乳腺癌的发病。
3. According to de Bock, "Due to the low prevalence of early breast cancer in the population, the predictive value of a family history of breast cancer was 13% before the age of 70, 11% before the age of 50, and 1% before the age of 30." These numbers are much lower than most women would probably expect. As the authors explain, "Applying family history related criteria results in the screening of many women who will not develop breast cancer at an early age."
Given the psychological harm that screening visits can cause, more stringent criteria should be applied to early screening. The researchers recommend that these results be used to "reassure a large number of women regarding their personal breast cancer risk."
de Bock的研究显示，由于早期乳腺癌的发病率本来较低，乳腺癌家族史对于早期乳腺癌的预测价值也不高，对于70岁以下的女性，预测价值13%；对于50岁以下的女性，预测价值11%；对于30岁以下的女性，预测价值仅1%。因此，家族史的预测价值远远地域大多数女性的期望值。作者解释：“将家族史作为风险因子，其实是将许多并不会在较年轻时发生乳腺癌的妇女都纳入了筛查的范畴。”由于疾病筛查本身会带来一些心理问题，所以，对于乳腺癌的早期筛查，其入选标准应当更加严格。研究人员希望，这一项研究能够“使一些担心罹患乳腺癌的妇女得到放松。” 最新的一项研究可以让乳腺癌患者的女性亲属们松一口气，因为结果表明，乳腺癌的家族史并不意味着一个女性发生乳腺癌的风险增加或时间提前。
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作者:admin@医学,生命科学 2011-06-23 19:15
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