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【Nature Immunology 编译】趋化因子受体对T细胞的协
T cell costimulation by chemokine receptors
来源
Nature Immunology 6, 465 - 471 (2005)
Published online: 10 April 2005; | doi:10.1038/ni1191
http://www.nature.com/ni/journal/v6/n5/abs/ni1191.html
摘要原文
Signals mediated by chemokine receptors may compete with T cell receptor stop signals and determine the duration of T cell−antigen-presenting cell interactions. Here we show that during T cell stimulation by antigen-presenting cells, T cell chemokine receptors coupled to Gq and/or G11 protein were recruited to the immunological synapse by a Gi-independent mechanism. When chemokine receptors were sequestered at the immunological synapse, T cells became insensitive to chemotactic gradients, formed more stable conjugates and finally responded with enhanced proliferation and cytokine production. We suggest that chemokine receptor trapping at the immunological synapse enhances T cell activation by improving T cell−antigen-presenting cell attraction and impeding the 'distraction' of successfully engaged T cells by other chemokine sources.
编译
趋化因子受体介导的信号可以与T细胞受体竞争从而阻断信号，决定T细胞和抗原提呈细胞相互作用的时间。我们发现，在抗原提呈细胞刺激T细胞的过程中，T细胞趋化因子受体与Gq 和（或）G11 蛋白通过非Gi依赖的机制一起聚集到免疫突触。当趋化因子受体在免疫突触消失时，T细胞变得对趋化性梯度不敏感。形成更加稳定的结合物，最终引起高度的增殖和细胞因子的产生。我们认为趋化因子受体在免疫突触捕获后，通过提高T细胞和抗原呈递细胞的吸引来加强T细胞的活化，并且通过其它来源的趋化因子阻碍成功激活的T细胞“分散”。
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作者:admin@医学,生命科学 2011-04-06 17:16
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