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【商业翻译—医师报约稿】Questions Over Drugs to P
2.本星期四（6.28）中午12点前交稿。
3.翻译并非简单直译，格式见版内置顶的文摘编译格式：
http://www.dxy.cn/bbs/post/view?bid=116&id=8600034&sty=1&tpg=1&age=0
4.稿酬按医师报标准。
5.为保证翻译质量起见，在本版得分超过15分以上的战友方可认领。
6.每位战友最多认领2篇。
7.作者统一署名为"丁香"
8.文中出现的杂志名称用原文，无需翻译。
Questions Over Drugs to Prevent Heart Complications During Surgery
Editorial: ß blockers and statins in non-cardiac surgery BMJ Volume 334 pp 1283-4
Newswise — The use of drugs to prevent heart complications during surgery is called into question in this week’s BMJ.
Globally, about 100 million adults have non-cardiac surgery (ie. on any part of the body other than the heart) each year. Around 1% are at risk of cardiac complications, such as heart attacks and strokes, and about one in four will die each year.
Two types of drugs – ß blockers and statins - are regularly given to patients to prevent such complications. They are given shortly before, during, or after surgery (the perioperative stage) to help lower blood pressure
But doctors in Australia now warn that the benefit of using these drugs at this time remains unclear.
They cite several large international studies that found no benefit from perioperative ß blockers.
Two studies from Denmark and the UK reported no reduction in death or several other serious complications, such as heart attack, heart failure, and stroke 30 days after surgery in patients receiving ß blockers. Another study found no benefit six months after surgery, and a trial currently underway has so far not reported any beneficial effects.
However, all studies did report significantly higher rates of important side effects with ß blockers, including slow heart beat (bradycardia) and very low blood pressure (hypotension). This has led to calls to examine the widespread use of perioperative ß blocking drugs.
Like ß blockers, statins have also been advocated to reduce the risk of perioperative cardiac complications, write the authors. Non-randomised trials suggest that statins confer benefit, but the evidence remains weak, and to prove a strong overall survival benefit would require a ‘gold-standard’ randomised controlled trial of more than 12,000 patients.
The benefits of statins in reducing cardiac complications in the general population and high risk patients are well known, but robust evidence to confirm that these drugs are valuable in routine perioperative use has not been published, they say.
So, on the basis of the evidence currently available, what should practising clinicians do?
They suggest that patients already receiving ß blockers or statins before surgery should continue with treatment. But no patient should start taking statins or ß blockers in the perioperative period specifically to reduce the likelihood of perioperative cardiac events. 本人已认领该文编译，如48小时未能提交译文，请其他战友自由认领 Questions Over Drugs to Prevent Heart Complications During Surgery
Editorial: ß blockers and statins in non-cardiac surgery BMJ Volume 334 pp 1283-4
关于手术期间药物可以阻止心脏并发症的疑问
评论：非心脏手术中ß阻滞剂和他汀类药物的应用。BMJ334卷，1283－1284
News wise — The use of drugs to prevent heart complications during surgery is called into question in this week’s BMJ.
新闻：手术期间防止心脏并发症的药物应用是本周BMJ的讨论问题。
Globally, about 100 million adults have non-cardiac surgery (ie. on any part of the body other than the heart) each year. Around 1% are at risk of cardiac complications, such as heart attacks and strokes, and about one in four will die each year.
全球每年大约有100,000,000成人进行非心脏手术（包括全身除心脏外的各个部位）。大约1％有并发心脏问题的风险，比如心脏病发作、卒中，并且每年大约有四分之一死亡。
Two types of drugs – ß blockers and statins - are regularly given to patients to prevent such complications. They are given shortly before, during, or after surgery (the perioperative stage) to help lower blood pressure
为预防这样的并发症出现，两种药物－ß阻滞剂和他汀类－被规律应用于患者。他们往往在术前、术中或术后（即围手术期）服药，来帮助降低血压。
But doctors in Australia now warn that the benefit of using these drugs at this time remains unclear.
但澳大利亚医生现在警告说，应用这时这些药物是否有益仍属未知。
They cite several large international studies that found no benefit from perioperative ß blockers.
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作者:admin@医学,生命科学 2011-04-17 17:14
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