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【medical-news】应用酸性成纤维细胞生长因子修复
Jau-Ching Wu, M.D.125, Wen-Cheng Huang, M.D.125, Yun-An Tsai, M.D.235, Yu-Chun Chen, M.D., M.Sc.245, and Henrich Cheng, M.D., Ph.D.126
1Department of Neurosurgery and 2Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital; 3Departments of Physical Medicine and Rehabilitation and 4Family Medicine, Taipei Veterans General Hospital; and 5School of Medicine and 6Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan
Abbreviations used in this paper: ASIA = American Spinal Injury Association; CA = carbohydrate antigen; FGF = fibroblast growth factor; SCI = spinal cord injury.
Address correspondence to: Henrich Cheng, M.D., Ph.D., Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Room 509, 17F, No. 201, Shih-Pai Road, Sec. 2, Peitou, Taipei 11217, Taiwan. email: hc_cheng@vghtpe.gov.tw.
DOI: 10.3171/SPI/2008/8/3/208
Object
The aim of this study was to assess functional outcomes of nerve repair using acidic fibroblast growth factor (FGF) in patients with cervical spinal cord injury (SCI).
Methods
Nine patients who had cervical SCI for longer than 5 months were included in pre- and postoperative assessments of their neurological function. The assessments included evaluating activities of daily living, associated functional ability, and degree of spasticity, motor power, sensation, and pain perception. After the first set of assessments, the authors repaired the injured segment of the spinal cord using a total laminectomy followed by the application of fibrin glue containing acidic FGF. Clinical evaluations were conducted 1, 2, 3, 4, 5, and 6 months after the surgery. Preoperative versus postoperative differences in injury severity and grading of key muscle power and sensory points were calculated using the Wilcoxon signed-rank test.
Results
The preoperative degree of injury severity, as measured using the American Spinal Injury Association (ASIA) scoring system, showed that preoperative motor (52.4 ± 25.9 vs 68.6 ± 21.5), pinprick (61.0 ± 34.9 vs 71.6 ± 31.0), and light touch scores (57.3 ± 33.9 vs 71.9 ± 30.2) were significantly lower than the respective postoperative scores measured 6 months after surgery (p = 0.005, 0.012, and 0.008, respectively).
Conclusions
Based on the significant difference in ASIA motor and sensory scale scores between the preoperative status and the 6-month postoperative follow-up, this novel nerve repair strategy of using acidic FGF may have a role in the repair of human cervical SCI. Modest nerve regeneration occurred in all 9 patients after this procedure without any observed adverse effects. This repair strategy thus deserves further investigation, clinical consideration, and refinement.
Keywords: acidic fibroblast growth factor; cervical spine; nerve repair; spinal cord injury.
http://thejns.org/doi/abs/10.3171/SPI/2008/8/3/208?journalCode=spi
本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Nerve repair using acidic fibroblast growth factor in human cervical spinal cord injury: a preliminary Phase I clinical study
应用酸性成纤维细胞生长因子修复人类颈脊髓损伤神经：I期临床试验
Object
The aim of this study was to assess functional outcomes of nerve repair using acidic fibroblast growth factor (FGF) in patients with cervical spinal cord injury (SCI).
目的:本研究的目的是评价应用酸性成纤维细胞生长因子修复颈脊髓损伤患者神经的功能性疗效。
Methods
Nine patients who had cervical SCI for longer than 5 months were included in pre- and postoperative assessments of their neurological function. The assessments included evaluating activities of daily living, associated functional ability, and degree of spasticity, motor power, sensation, and pain perception. After the first set of assessments, the authors repaired the injured segment of the spinal cord using a total laminectomy followed by the application of fibrin glue containing acidic FGF. Clinical evaluations were conducted 1, 2, 3, 4, 5, and 6 months after the surgery. Preoperative versus postoperative differences in injury severity and grading of key muscle power and sensory points were calculated using the Wilcoxon signed-rank test.
方法：9例颈脊髓损伤患者，病程至少5个月，评价其术前术后神经功能，内容包括日常生活活动、联合功能性活动、痉挛分级、肌力、感觉以及痛觉。第一次评价后，作者采用全椎板切除术修复损伤节段，随后应用含有酸性成纤维细胞生长因子的纤维蛋白胶。分别于术后1、2、3、4、5及6月份进行临床评价。采用秩和检验对比术前术后损伤严重度、关键肌的肌力分级以及感觉关键点进行评价。
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作者:admin@医学,生命科学 2011-04-17 05:11
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