mitotic checkpoint: lethality to human cancer cells
A compromised mitotic checkpoint, the primary mechanism for ensuring that each new cell receives one copy of every chromosome, has been implicated as a contributor to carcinogenesis. However, a checkpoint response is shown here to be essential for cell survival, including that of chromosomally instable colorectal cancer cells. Reducing the levels of the checkpoint proteins BubR1 or Mad2 in human cancer cells or inhibiting BubR1 kinase activity provokes apoptotic cell death within six divisions except when cytokinesis is also inhibited. Thus, suppression of mitotic checkpoint signaling is invariably lethal as the consequence of massive chromosome loss, findings that have implications for inhibiting proliferation of tumor cells.
PNAS | June 8, 2004 | vol. 101 | no. 23 | 8699-8704
http://www.pnas.org/cgi/content/full/101/23/8699
[标签:content1][标签:content2]
阅读本文的人还阅读：
【Clin Cancer Res】利用MK
p53 Protocols已由human pres
【Cancer research】有前景的
【bio-news】CHD5 Is a Tumor
【Cancer cell】日本研究人
作者:admin@医学,生命科学 2011-04-17 05:14
医学,生命科学网
