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【drug-news】针头大小的蠕虫+机器人=新型抗生素？
Pinhead-size Worms + Robot = New Antibiotics
ScienceDaily (Aug. 20, 2009) — In an advance that could help ease the antibiotic drought, scientists in Massachusetts are describing successful use of a test that enlists pinhead-sized worms in efforts to discover badly needed new antibiotics.
Frederick Ausubel and colleagues note in the new study that existing methods for identifying germ-fighting drugs involve adding the potential drug to cultures of bacteria or cells and watching the results. These tests sometimes do not work well. They may give passing grades to potential drugs that are toxic, or that fight bacteria in the same ways as existing antibiotics that are loosing effectiveness against drug-resistant bacteria.
A much better test would involve screening of potential new antibiotics in living animals infected with bacteria to see the effects on the entire body of the animal.
The scientists describe successful use of such a whole-animal high throughput screening test — automated with a robot — to test the effects of 37,000 potential drugs on C. elegans (a type of worm) infected with E. faecalis (a type of bacteria). That bacterium causes life-threatening infections in humans. C. elegans are tiny nematode worms that are widely used in scientific research.
The tests identified 28 potential new drugs never before reported to have germ-fighting effects. Some of the potential new drugs worked in ways that appeared to be totally different than existing antibiotics.
C. elegans. This pinhead-sized worm could play an important role in discovering and testing new antibiotics, researchers say. (Credit: Wikimedia Commons) 本人已认领本文翻译48小时未提交请其他战友继续认领 Pinhead-size Worms + Robot = New Antibiotics
针头样大小蠕虫+机器人=新抗生素
ScienceDaily (Aug. 20, 2009) — In an advance that could help ease the antibiotic drought, scientists in Massachusetts are describing successful use of a test that enlists pinhead-sized worms in efforts to discover badly needed new antibiotics.
每日科学（2009.8.20）-- 技术的进步有助于易化抗生素发现，马萨诸塞州的科学家介绍了将针头样大小的蠕虫成功应用于发现急需新抗生素的实验。
Frederick Ausubel and colleagues note in the new study that existing methods for identifying germ-fighting drugs involve adding the potential drug to cultures of bacteria or cells and watching the results. These tests sometimes do not work well. They may give passing grades to potential drugs that are toxic, or that fight bacteria in the same ways as existing antibiotics that are loosing effectiveness against drug-resistant bacteria.
Frederick Ausubel和他的同事指出，新研究表明，目前已存的鉴定抗菌药物的方法需要在细菌培养物或细胞中加入可能的药物并观察结果。有时，这些实验的效果并不好。通过这种方法，可能使一些具有毒性或者与已存抗生素具有相同抗菌作用而由于细菌存在抗药性而已失去抗菌作用的药物通过评级。
A much better test would involve screening of potential new antibiotics in living animals infected with bacteria to see the effects on the entire body of the animal.
更好的检测方法应该在感染细菌的活体动物中筛选潜在的新型抗生素，以观察其对动物整体的影响。
The scientists describe successful use of such a whole-animal high throughput screening test — automated with a robot — to test the effects of 37,000 potential drugs on C. elegans (a type of worm) infected with E. faecalis (a type of bacteria). That bacterium causes life-threatening infections in humans. C. elegans are tiny nematode worms that are widely used in scientific research.
科学家介绍了成功应用这种全动物高通量筛选试验（并通过机器人完成自动化）。他们在感染粪肠球菌（一种细菌）的秀丽隐杆线虫（一种蠕虫）中检测37，000潜在药物的药效。这种细菌可以引其人类致命性感染。秀丽隐杆线虫是一种广泛用于科学研究的线虫。
The tests identified 28 potential new drugs never before reported to have germ-fighting effects. Some of the potential new drugs worked in ways that appeared to be totally different than existing antibiotics.
本实验鉴定了28种过去未曾报道过的具有抗菌作用的新药。并且，其中一些潜在的新药其作用方式与现存的抗生素完全不同。
C. elegans. This pinhead-sized worm could play an important role in discovering and testing new antibiotics, researchers say.
秀丽隐杆线虫（C. elegans）。研究者称，这些针头样大小的蠕虫可能在新药发现和检测中起重要的作用。
针头样大小蠕虫+机器人=新抗生素
每日科学（2009.8.20）-- 技术的进步有助于易化抗生素发现，马萨诸塞州的科学家介绍了将针头样大小的蠕虫成功应用于发现急需新抗生素的实验。
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作者:admin@医学,生命科学 2010-11-24 05:11
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