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【medical-news】研究揭示了前驱糖尿病与2型糖尿病

新闻来源:http://www.docguide.com/news/content.nsf/news/852571020057CCF6852572A500570F12?OpenDocument&id=48dde4a73e09a969852568880078c249&c=Diabetes&count=10
Study Reveals "Missing Link" Between Pre-Diabetes & Type 2 Diabetes

JACKSONVILLE, FL -- March 21, 2007 -- New research suggests a "missing link" between the pre-diabetes state and the clinical diagnosis of type 2 diabetes mellitus. These findings will be presented at the American Association of Clinical Endocrinologists Sixteenth Annual Meeting and Clinical Congress, which will be held April 11-16 at the Washington State Convention & Trade Center in Seattle.

Both impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are intermediate states in the transition from normal glucose tolerance (NGT) toT2DM and have been termed as "pre-diabetes". They are associated with a high risk for progression to T2DM.

Hepatic glucose production (HGP) is the principal determinant of fasting plasma glucose (FPG). In the current study, the authors have demonstrated that, in the non-diabetic range, the rise in fasting plasma glucose (FPG) concentration is associated with a mild decrease in hepatic glucose production (HGP) and a marked decrease in the glucose clearance rate.

"During the fasting state, the decrease in glucose clearance results in an increase in FPG concentration which stimulates basal insulin secretion. The rise in fasting plasma insulin concentration, in turn, inhibits HGP, thus attenuating the rise in FPG," Rucha Jani, MD, of the University of Texas Health Science Center in San Antonio and the study's author said. "The high fasting blood glucose in these subjects can thus be explained by the decrease in glucose clearance. This is an important observation as it provides insight into the pathogenic mechanisms that characterize the 'pre-diabetic' stage."

"Pinpointing the missing link is quite important," Jani said. "It allows us to identify potential future targets in order to develop effective therapies to prevent the progression from pre-diabetes to type 2 diabetes." 本人已认领该文编译,48小时后若未提交译文,请其他战友自由认领。 本人已认领该文编译,48小时后若未提交译文,请其他战友自由认领。

译文
Study Reveals "Missing Link" Between Pre-Diabetes & Type 2 Diabetes
研究揭示了前驱糖尿病与获得临床诊断的2型糖尿病之间的一个未知环节
JACKSONVILLE, FL -- March 21, 2007 -- New research suggests a "missing link" between the pre-diabetes state and the clinical diagnosis of type 2 diabetes mellitus. These findings will be presented at the American Association of Clinical Endocrinologists Sixteenth Annual Meeting and Clinical Congress, which will be held April 11-16 at the Washington State Convention & Trade Center in Seattle.
弗罗里达•杰克逊维尔2007.03.21—最新的研究揭示了前驱糖尿病与获得临床诊断的2型糖尿病之间的一个未知环节。这些发现将在美国临床内分泌专家协会第16界年度会议及临床代表大会上被予以公布,此次会议将于5月11-16日在华盛顿州西雅图的会议-贸易中心内举行。
Both impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are intermediate states in the transition from normal glucose tolerance (NGT) toT2DM and have been termed as "pre-diabetes". They are associated with a high risk for progression to T2DM.
空腹血糖受损(IFT)与糖耐量受损(IGT)均属于正常葡萄糖耐受(NGT)向前驱糖尿病(T2DM)转化过程中的过度态,它们也与发展为T2DM的高风险相关。
Hepatic glucose production (HGP) is the principal determinant of fasting plasma glucose (FPG). In the current study, the authors have demonstrated that, in the non-diabetic range, the rise in fasting plasma glucose (FPG) concentration is associated with a mild decrease in hepatic glucose production (HGP) and a marked decrease in the glucose clearance rate.
肝脏葡萄糖产量(HGP)是空腹血糖的主要来源(FPG)。在最新的研究中,研究者已经证明,在非糖尿病范畴内,空腹血糖(FPG)的升高伴有肝脏葡萄糖产量(HGP)轻微降低与葡萄糖清除率显著降低。
"During the fasting state, the decrease in glucose clearance results in an increase in FPG concentration which stimulates basal insulin secretion. The rise in fasting plasma insulin concentration, in turn, inhibits HGP, thus attenuating the rise in FPG," Rucha Jani, MD, of the University of Texas Health Science Center in San Antonio and the study's author said. "The high fasting blood glucose in these subjects can thus be explained by the decrease in glucose clearance. This is an important observation as it provides insight into the pathogenic mechanisms that characterize the 'pre-diabetic' stage."

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作者:admin@医学,生命科学    2011-01-13 17:14
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