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【medical-news】Obesity affects survival odds for ovarian c
According to research in the U.S. obese women get more aggressive ovarian cancers, have a shorter time before the cancer recurs and a shorter survival compared to women who are not obese.
Ovarian cancer can occur at any age, but is most common after the menopause. A woman's risk of getting ovarian cancer during her lifetime is about 1 in 58. The risk of getting this cancer and dying from it is 1 in 98.
Ovarian cancers are difficult to diagnose and by the time it is diagnosed, most women are in the late stages of the disease and about 70% die within five years, making it one of the most lethal cancers.
This is not the first time that obesity has been implicated in increasing the risk for developing certain cancers and obesity has also been linked with worse outcomes for some patients with cancer.
Other studies have found a compound called insulin-like growth factor 1 (IGF-1) is more evident in obese people than those who are slimmer and IGF-1 correlates with increased breast cancer risk in women.
This study however suggests fat tissue might also affect how a tumour progresses and the researchers believe fat cells excrete a hormone or protein that makes ovarian cancer cells grow more aggressively.
The researchers from the Cedars-Sinai Medical Research Center in California recently carried out an evaluation from data on body mass index and outcomes among patients diagnosed with ovarian cancer.
In a study which involved 216 patients the researchers looked at the disease course of epithelial ovarian cancer - the most common type of ovarian tumours, accounting for 90% of cases. They all had various stages of ovarian cancer and underwent surgery for their cancer at Cedars Sinai Medical Center between 1996 and 2003.
The team found that of the 149 patients diagnosed with advanced ovarian cancer, those with an increased body weight had a significantly reduced time before a cancer recurrence and a decreased survival time.
The researchers say this indicates that patients with advanced ovarian cancer have a significantly worse outcome if they are obese.
The results add support to a growing body of evidence that obesity is associated with worse outcomes among patients with cancer and experts agree that maintaining a healthy weight is one of the best ways to reduce the chances of getting cancer.
Lead researcher Dr. Andrew Li says the study is the first to identify weight as an independent factor in ovarian cancer, in disease progression and overall survival, which he says suggests there is an element in the fat tissue itself that influences the outcome of the disease in obese women.
Dr. Li says the next step will be to examine exactly how fat might influence tumour growth.
The research is published in the online version of the journal Cancer.
肥胖影响卵巢癌患者的生存率
根据美国研究者的报道肥胖的女性较其他人更有可能患侵袭性的卵巢癌，且复发间隔期和生存期也更短。
卵巢癌可以发生在任何一个年龄段，但最好发于绝经后。女性的发病比例为1/58，患病并死于此病的比例为1/98。
卵巢癌的诊断困难，到诊断时往往已经是晚期，大约70%的妇女在5年内死于此病，使之成为最常见致死性癌症之一。
肥胖并不是第一次被认为能增加癌症发展的危险性，且肥胖与一些癌症患者的预后较差有关。
其他的研究者发现肥胖人群中一种叫做IGF-1的化合物水平比瘦人明显高，而IGF-1与女性的乳腺癌相关。
这项研究提出脂肪组织可能也影响肿瘤的进展，研究者认为脂肪细胞产生一种激素或蛋白能够使卵巢癌细胞更具有侵袭性。
来自加利福尼亚州Cedara-Sinai医学研究中心的学者们最近完成了卵巢癌患者的肿块索引和预后的数据评价。
研究者回顾了216位卵巢上皮癌患者的发病过程，上皮癌是卵巢癌最常见的类型，占了90%。这些患者处于卵巢癌的不同阶段，并于1996-2003年期间在Cedara-Sinai医学中心进行了外科手术。
研究发现149位进展期卵巢癌患者中体重大的复发间隔期短，生存时间也短。
研究者说这表明肥胖的进展期卵巢癌患者会有较差的预后。
研究认为癌症患者中肥胖与预后差有关系，专家也赞同保持健康的体重是减少癌症发病率的最好途径之一。
Andrew Li医生是研究的主要负责人，他说这项研究是首次把体重做为卵巢癌分级、评估预后的一个独立因素。他提示脂肪组织中有一种物质能影响肥胖的卵巢癌患者的预后。
Li医生说他们下一步将研究脂肪如何影响肿瘤生长。
这项研究发表在《癌症》期刊的翻译本上。 body mass index 是体重指数，即体重（千克）/身高的平方（平方米），曾经有报道在判定女性性感程度时BMI要优于Waist-to-hip ratio。 性感程度 谢谢liven 版主！ 有关BMI刚刚有新的热点：
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作者:admin@医学,生命科学 2011-01-14 17:14
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