A new way of signaling has been detected for one of the most highly studied hormone receptors: the insulin and the related insulin-like growth factor receptors. These receptors, when activated by ligand binding, initiate signaling mechanisms that protect cells from apoptosis and favor cell survival. Thus Boucher et al. were surprised to find that in mouse brown adipose tissue cell lines, the loss of both receptors in the same cell actually made cells resistant to stimuli that normally promote apoptosis. Ligand deprivation of receptor-expressing cells, however, did not cause this effect. This suggests that the receptors, in the absence of hormone binding, are not “turned off” but rather appear to be producing a signal that is permissive for cell death. The receptors thus join a family known as “dependence receptors” because in their presence, a cell is addicted to the presence of growth factor in order to prevent the proapoptotic effect of the unliganded receptor.
医药生命科学动态跟踪 -【版助申请】申请【医药生命科学动态跟踪】版版助,谢谢大家! 小路昭昭 【medical-... “举轻”堪比“举重” badimala 【Science】推介论文:抗凋亡诱导抗肿瘤 lgq7018 【...www.ruanjian520.com/...22.html-2010-09-05-快照-医药生命科学动态跟踪 -" 一、生物医药:文件类型:DOC/Microsoft Word- 文字版血液系统肿瘤(如白血病等)的发病率、死亡率逐年上升,目前尚缺乏满意的治疗手段.白血... 为病人和医生跟踪治疗进展,监测癌细胞对药物的反应,及实施新的治疗方案提供科学依据. ...www.fjrs.gov.cn/...0576345.doc-2010-11-11-医药:" 药学快讯(版权页)文件类型:PDF/Adobe Acrobat- 文字版行业动态.61 2007 年医药行业投资策略:锁定 10 只龙头.61 美国新药临床研究投入续增.... (http://www.sdrug.com/information/medicine-science-news/2006/46278.html) 科学家最新...www.lib.gdpu.edu.cn/...541.pdf-2011-01-06-药学快讯(版权页)"[标签:content2]
作者:admin@医学,生命科学 2011-01-15 00:05