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【medical-news】新型减肥药也有治疗糖尿病功效
新型减肥药也有治疗糖尿病功效
By Maggie Fox, Health and Science Editor Maggie Fox, Health And Science Editor – Thu Aug 27, 5:44 pm ET
WASHINGTON (Reuters) – Researchers searching for a cure for obesity said on Thursday they have developed a drug that not only makes mice lose weight, but reverses diabetes and lowers their cholesterol, too.
The drug, which they have dubbed fatostatin, stops the body from making fat, instead releasing the energy from food. They hope it may lead to a pill that would fight obesity, diabetes and cholesterol, all at once.
Writing in the journal Chemistry and Biology, Salih Wakil of Baylor College of Medicine in Texas, Motonari Uesugi of Kyoto University in Japan and colleagues said the drug interferes with a suite of genes turned on by overeating.
"Here, we are tackling the basics," Wakil said in a telephone interview. "I think that is what excited us."
Scientists are painfully aware that drugs that can make mice thin do nothing of the sort in humans. A hormone called leptin can make rats and mice drop weight almost miraculously but does little or nothing for an obese person, for instance.
But Wakil, whose team has patented the drug and is looking for a drug company to partner with, hopes this drug may be different. "I am very, very optimistic," he said.
Fatostatin is a small molecule, meaning it has the potential to be absorbed in pill form.
It works on so-called sterol regulatory element binding proteins or SREBPs, which are transcription factors that activate genes involved in making cholesterol and fatty acids.
"Fatostatin blocked increases in body weight, blood glucose, and hepatic (liver) fat accumulation in (genetically) obese mice, even under uncontrolled food intake," the researchers wrote.
Genetic tests showed the drug affected 63 different genes.
The idea of interfering with SREBP is not new. GlaxSmithKline has been working on a new-generation cholesterol drug that uses this pathway.
After four weeks, mice injected with fatostatin weighed 12 percent less and had 70 percent lower blood sugar levels, the researchers wrote.
Now they plan to test rats and rabbits, Wakil said.
The drug also had effects on prostate cancer cells they said -- something that may help explain links between prostate cancer and obesity.
http://news.yahoo.com/s/nm/20090827/hl_nm/us_obesity_fatostatin New fat-fighting drug has anti-diabetes action too
新型减肥药显示多重作用----降糖降胆固醇
WASHINGTON (Reuters) – Researchers searching for a cure for obesity said on Thursday they have developed a drug that not only makes mice lose weight, but reverses diabetes and lowers their cholesterol, too.
华盛顿路透社新闻----减肥药研究者周三称已经研究出一种药物，不仅减低了小鼠的体重，而且降低了血糖和胆固醇。
The drug, which they have dubbed fatostatin, stops the body from making fat, instead releasing the energy from food. They hope it may lead to a pill that would fight obesity, diabetes and cholesterol, all at once.
这个药物，研究者将之称为fatostatin，可阻止机体生成脂肪，而不是从食物释放能量。研究者希望它可以被开发成可用来对抗肥胖，糖尿病和高胆固醇的片剂。
Writing in the journal Chemistry and Biology, Salih Wakil of Baylor College of Medicine in Texas, Motonari Uesugi of Kyoto University in Japan and colleagues said the drug interferes with a suite of genes turned on by overeating.
相关研究刊登在化学与生物学杂志上，来自美国德州和日本的合作研究者声称这种药物通过干预一组由过度饮食启动的基因而发挥作用。
"Here, we are tackling the basics," Wakil said in a telephone interview. "I think that is what excited us."
我们正在进行基础方面的研究，结果是振奋人心的。研究者接受访问时说。
Scientists are painfully aware that drugs that can make mice thin do nothing of the sort in humans. A hormone called leptin can make rats and mice drop weight almost miraculously but does little or nothing for an obese person, for instance.
长期以来有个问题使科学家们一直都很头疼----多数能够使小鼠变瘦的药物在人类肥胖的治疗上不起作用。例如，一种叫做瘦素的荷尔蒙能够在大鼠和小鼠身上取得奇迹般的减肥效果，但是对胖人却几乎没有什么作用。
But Wakil, whose team has patented the drug and is looking for a drug company to partner with, hopes this drug may be different. "I am very, very optimistic," he said.
研发团队已经为该药物申请了专利并正在寻找合作的公司，希望这个药物与众不同，对这个药物的前景研究者的态度非常乐观。
Fatostatin is a small molecule, meaning it has the potential to be absorbed in pill form.
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作者:admin@医学,生命科学 2010-10-13 05:11
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