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【Thyroid】黑钙土相关的儿童甲状腺乳头状癌的形
Morphologic Characteristics of Chernobyl-Related Childhood Papillary Thyroid Carcinomas Are Independent of Radiation Exposure but Vary with Iodine Intake
E. Dillwyn Williams,1 Alexander Abrosimov,2 Tatiana Bogdanova,3 Evgeny P. Demidchik,4 Masahiro Ito,5
Virginia LiVolsi,6 Evgeny Lushnikov,2 Juan Rosai,7 Mikola D. Tronko,3 Anatoly F. Tsyb,2
Sarah L. Vowler,8 and Geraldine A. Thomas9
Background: The Chernobyl accident caused an unprecedented increase in papillary thyroid carcinoma (PTC) incidence with a surprisingly short latency and unusual morphology. We have investigated whether unexpected features of the PTC incidence after Chernobyl were radiation specific or influenced by iodine deficiency.
Methods: PTCs from children from Belarus, Ukraine, and the Russian Federation exposed to fallout from Chernobyl were compared with PTCs from children not exposed to radiation from the same countries, from England and Wales (E&W) and from Japan. The degree and type of differentiation, fibrosis, and invasion were quantified.
Results: There were no significant differences between PTCs from radiation-exposed children from Belarus, Ukraine, and the Russian Federation and PTCs from children from the same countries who were not exposed to radiation. Childhood PTCs from Japan were much more highly differentiated (p < 0.001), showed more papillary differentiation (p < 0.001) and were less invasive (p < 0.01) than “Chernobyl” tumors, while tumors from E&W generally showed intermediate levels of degree and type of differentiation and invasion. There was a marked difference between the sex ratios of children with PTCs who were radiation exposed and those who were not exposed (F:M exposed vs. unexposed 1.5:1 vs. 4.2:1; χ2 = 7.90, p ≤ 0.01005).
Conclusions: The aggressiveness and morphological features of Chernobyl childhood PTCs are not associated with radiation exposure. The differences found between tumors from the Chernobyl area, E&W, and Japan could be influenced by many factors. We speculate that dietary iodine levels may have wide implications in radiation-induced thyroid carcinogenesis, and that iodine deficiency could increase incidence, reduce latency, and influence tumor morphology and aggressiveness. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 虽然每天只进步1%，但每天都超越了昨天，如此日有所进，月有所变，用心写好每天进步1%的加号，不论钻研什么学问、从事什么工作，都能享受胜利的喜悦、达到理想的高峰。因此，我们应该珍惜这每天的进步，争取每天有进步。可以说，成功往往不是看谁哪一阶段跑得最快，而是看谁前进的步伐更持久。 Morphologic Characteristics of Chernobyl-Related Childhood Papillary Thyroid Carcinomas Are Independent of Radiation Exposure but Vary with Iodine Intake
黑钙土相关的儿童甲状腺乳头状癌的形态学特征不依赖于放射线暴露但与碘摄入水平有关
E. Dillwyn Williams,1 Alexander Abrosimov,2 Tatiana Bogdanova,3 Evgeny P. Demidchik,4 Masahiro Ito,5
Virginia LiVolsi,6 Evgeny Lushnikov,2 Juan Rosai,7 Mikola D. Tronko,3 Anatoly F. Tsyb,2
Sarah L. Vowler,8 and Geraldine A. Thomas9
Background: The Chernobyl accident caused an unprecedented increase in papillary thyroid carcinoma (PTC) incidence with a surprisingly short latency and unusual morphology. We have investigated whether unexpected features of the PTC incidence after Chernobyl were radiation specific or influenced by iodine deficiency.
背景：黑钙土导致短潜伏期和异常形态的乳头状甲状腺癌(PTC)的发生。我们希望通过调查明确黑钙土相关的PTC的异常特征是否与放射暴露或碘缺乏相关。
Methods: PTCs from children from Belarus, Ukraine, and the Russian Federation exposed to fallout from Chernobyl were compared with PTCs from children not exposed to radiation from the same countries, from England and Wales (E&W) and from Japan. The degree and type of differentiation, fibrosis, and invasion were quantified.
方法：比较来自白俄罗斯,乌克兰、俄罗斯联邦、英格兰和威尔士地区和日本的暴露于放射性的黑钙土的PTC患儿和来自同一地区的未接触放射性物质的患儿。对肿瘤的分化程度和类型、纤维化程度和浸润程度进行量化。
Results: There were no significant differences between PTCs from radiation-exposed children from Belarus, Ukraine, and the Russian Federation and PTCs from children from the same countries who were not exposed to radiation. Childhood PTCs from Japan were much more highly differentiated (p < 0.001), showed more papillary differentiation (p < 0.001) and were less invasive (p < 0.01) than “Chernobyl” tumors, while tumors from E&W generally showed intermediate levels of degree and type of differentiation and invasion. There was a marked difference between the sex ratios of children with PTCs who were radiation exposed and those who were not exposed (F:M exposed vs. unexposed 1.5:1 vs. 4.2:1; χ2 = 7.90, p ≤ 0.01005).
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作者:admin@医学,生命科学 2011-04-26 05:11
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