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【编译】万艾可有损视力
明尼苏达大学的Howard D. Pomeranz博士指出，长久以来，我们已发现患者在服用了万艾可之后，会有短暂的色彩视觉问题，比如将蓝色事物的看成是绿色的。然而，NAION是一种更为严重的眼病，足以导致人失明。
除了1名患者在服药后24-36小时内表现出了NAION的症状，其余患者都在服药后24小时内发病。最初，他们视力模糊，然后有不同程度的视力丧失。大多数患者只是单眼发病，只有一名患者累及双眼。
所有的病人都有一种以上的心脏病危险因素——常见高血压，偶有高血脂。三名患者之前就患有眼病，因此将会加重NAION的危险。
最终，患者的视力可能被削弱到只有光亮的微弱感知。
这一研究发表在3月份的《神经眼科学杂志(Journal of Neuro-Ophthalmology)》上。
Pomeranz博士在接受路透社采访时指出，治疗ED的药物通常会和NAION相联系，之前普遍使用的西力士（他地那非）也是如此。虽然目前发现的NAION病例可能只是冰山一角，但是博士强调，这类药物引起NAION的危险性还是相当低的。
因此，目前还没有足够的数据表明需要对每个万艾可服用者进行眼科检查。但是，博士仍旧认为医生在给病人开药时，应当对NAION患者和严重心脏病危险者说明这一点，并且建议他们进行眼科检查。
对这一消息，万艾可的生产商辉瑞公司尚未发表任何声明。
delman编译自www.Reuters.com
http://today.reuters.com/news/newsArticle.aspx?type=healthNews&storyID=2005-03-30T224331Z_01_B669211_RTRIDST_0_HEALTH-VISION-VIAGRA-DC.XML
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By Anthony J. Brown, MD
NEW YORK (Reuters Health) - In a new study, US researchers describe seven patients who developed nonarteritic ischemic optic neuropathy (NAION), an eye problem that can result in permanent vision loss, after taking Viagra (sildenafil) for erection difficulties. Combined with past reports, this study brings the total number of sildenafil-related NAION cases to 14.
"For years, we've known that some men who take Viagra will experience temporary color changes in their vision and see things as blue or green," study co-author Dr. Howard D. Pomeranz, from the University of Minnesota in Minneapolis, said in a statement. "NAION is a much more serious condition because it can lead to permanent vision loss."
With the exception of one patient whose symptoms began 24 to 36 hours after using Viagra, the patients developed symptoms within 24 hours of use. In all patients, the initial symptoms were blurred vision and some degree of vision loss. In one patient, both eyes were affected, whereas in the remainder, just one was involved.
All of the patients had one or more heart disease risk factors. High blood pressure was invariably present and most men also had high cholesterol levels. Three patients had preexisting eye problems that may have increased their risk of NAION.
The final vision in the patients' affected eye ranged from perfect vision to only light perception, the investigators note in the Journal of Neuro-Ophthalmology.
Pomeranz told Reuters Health that Viagra's association with NAION appears to involve all drugs of this type, as reports have surfaced implicating Cialis (tadalafil) use as well. Although these cases may just represent the "tip of the iceberg," he said that the risk of NAION with these drugs is probably still very, very small.
"At this point, there are not enough data to support performing an ophthalmologic exam on every patient being considered for" Viagra treatment, Pomeranz noted. Still, he said that doctors prescribing the drug should be aware of the association with NAION and consider an exam for patients with several heart disease risk factors.
A representative from Pfizer, the maker of Viagra, was not immediately available for comment.
SOURCE: Journal of Neuro-Ophthalmology, March 2005.
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作者:admin@医学,生命科学 2011-03-13 05:11
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