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【medical-news】乳腺癌发病风险与生育时间有关
Thu Feb 14, 10:56 AM ET
NEW YORK (Reuters Health) - A longer interval between the age a woman first begins to menstruate and her age when she first gives birth is associated with an increased risk of breast cancer, the results of a study published in the American Journal of Epidemiology suggests.
Age at menstruation and first birth are "established risk factors for breast cancer," Dr. Christopher I. Li, of the Fred Hutchinson Cancer Research Center, Seattle, and colleagues write. The interval between these ages may also influence breast cancer risk because the breast becomes more susceptible to carcinogenic exposure during this period , they note. "However, few investigators have studied this relation."
To investigate further, Li's group used data from the Women's Contraceptive and Reproductive Experiences Study (1994 to 1998), including 4,013 women with breast cancer and 4,069 women without breast cancer (the controls).
Among the white women, those who were premenopausal, had given birth and who also had an interval of at least 16 years from when they began to menstruate and their first birth had a 1.5-fold increased risk of breast cancer compared to those who had fewer than 5 years between these ages. This association was not observed among premenopausal African-American women.
The increased risks were mainly confined to women with hormone-receptor-positive tumors and tumors located in the breast lobules.
The results associating age at first full-term birth and breast cancer risk are generally consistent with previous results, but the findings regarding age at first menstruation are not, Li's team adds.
"Epidemiologic studies of both premenopausal and postmenopausal women have consistently found that breast cancer risk is reduced 5 to 20 percent for each year (menstruation) is delayed," they explain. However, in this study an older age at first (menstruation) was not associated with a reduced risk of breast cancer."
SOURCE: American Journal of Epidemiology, January 2008. 本人认领，若12小时未提交编译，请其他战友认领。 Breast cancer risk linked with fertility timing
Thu Feb 14, 10:56 AM ET
乳腺癌发病风险与生育时间有关
NEW YORK (Reuters Health) - A longer interval between the age a woman first begins to menstruate and her age when she first gives birth is associated with an increased risk of breast cancer, the results of a study published in the American Journal of Epidemiology suggests.
据《美国流行病学杂志》上发表的一项研究结果表明，女性从月经初潮到首次生育的时间间隔越长，则发生乳腺癌的几率增加。
Age at menstruation and first birth are "established risk factors for breast cancer," Dr. Christopher I. Li, of the Fred Hutchinson Cancer Research Center, Seattle, and colleagues write. The interval between these ages may also influence breast cancer risk because the breast becomes more susceptible to carcinogenic exposure during this period , they note. "However, few investigators have studied this relation."
西雅图弗雷德•哈金森癌症研究中心的克里斯多佛-李医生及其同事在论文中指出，初潮和首次生育年龄是乳腺癌确定的风险因子。初潮和首次生育年龄间隔也可能影响乳腺癌风险，这是因为乳腺在这一阶段更容易受致癌物质的影响。但是，目前几乎没有研究人员对此进行研究。
To investigate further, Li's group used data from the Women's Contraceptive and Reproductive Experiences Study (1994 to 1998), including 4,013 women with breast cancer and 4,069 women without breast cancer (the controls).
为此，李的研究团队对“妇女避孕和生殖经历研究（1994-1998）”的数据进行了研究，该研究纳入了4013名乳腺癌妇女和4069名非乳腺癌妇女。
Among the white women, those who were premenopausal, had given birth and who also had an interval of at least 16 years from when they began to menstruate and their first birth had a 1.5-fold increased risk of breast cancer compared to those who had fewer than 5 years between these ages. This association was not observed among premenopausal African-American women.
在有生育史的绝经前白人妇女中，初潮和首次生育年龄间隔大于16年的妇女与年龄间隔小于5年的妇女相比，其乳腺癌风险提高1.5倍。而在绝经前的美国黑人妇女中未发现这一相关性。
The increased risks were mainly confined to women with hormone-receptor-positive tumors and tumors located in the breast lobules.
这一风险主要见于患有激素受体阳性和乳腺小叶肿瘤的妇女。
The results associating age at first full-term birth and breast cancer risk are generally consistent with previous results, but the findings regarding age at first menstruation are not, Li's team adds.
本研究所表明的首次足月产妇年龄与乳腺癌的相关性与以前的研究结果相一致，但有关初潮年龄却不同。
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作者:admin@医学,生命科学 2011-03-12 23:54
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